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Two Distinct Clinical Courses of Human Cowpox, Germany, 2015

Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case—an unvaccinated young veterinary assistant—a pustule was treated locally with cortisone. The lesion turned into a...

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Autores principales: Eder, Ines, Vollmar, Patrick, Pfeffer, Martin, Naether, Philipp, Rodloff, Arne Christian, Meyer, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744150/
https://www.ncbi.nlm.nih.gov/pubmed/29215552
http://dx.doi.org/10.3390/v9120375
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author Eder, Ines
Vollmar, Patrick
Pfeffer, Martin
Naether, Philipp
Rodloff, Arne Christian
Meyer, Hermann
author_facet Eder, Ines
Vollmar, Patrick
Pfeffer, Martin
Naether, Philipp
Rodloff, Arne Christian
Meyer, Hermann
author_sort Eder, Ines
collection PubMed
description Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case—an unvaccinated young veterinary assistant—a pustule was treated locally with cortisone. The lesion turned into a large ulcer accompanied by severe lymphadenitis. Based on her close contact to a sick stray cat, infection with cowpox virus was assumed and confirmed by virus isolation, PCR, and serology. The clinical course took up to eleven months until healing of the wound was complete. Transmission of cowpox virus from the cat was likely because a skin swab was PCR-positive and the cat had a high titer of anti-orthopoxvirus antibodies. In contrast, a rather mild clinical course of cowpox was confirmed in a 49-year-old male farmer vaccinated against smallpox. Only a small eschar developed, and wound closure was complete after 6 weeks.
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spelling pubmed-57441502017-12-31 Two Distinct Clinical Courses of Human Cowpox, Germany, 2015 Eder, Ines Vollmar, Patrick Pfeffer, Martin Naether, Philipp Rodloff, Arne Christian Meyer, Hermann Viruses Case Report Here we present two cases of human infection with cowpox virus with distinct clinical courses. A series of clinical photographs documents lesion progression over time. In the first case—an unvaccinated young veterinary assistant—a pustule was treated locally with cortisone. The lesion turned into a large ulcer accompanied by severe lymphadenitis. Based on her close contact to a sick stray cat, infection with cowpox virus was assumed and confirmed by virus isolation, PCR, and serology. The clinical course took up to eleven months until healing of the wound was complete. Transmission of cowpox virus from the cat was likely because a skin swab was PCR-positive and the cat had a high titer of anti-orthopoxvirus antibodies. In contrast, a rather mild clinical course of cowpox was confirmed in a 49-year-old male farmer vaccinated against smallpox. Only a small eschar developed, and wound closure was complete after 6 weeks. MDPI 2017-12-07 /pmc/articles/PMC5744150/ /pubmed/29215552 http://dx.doi.org/10.3390/v9120375 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Eder, Ines
Vollmar, Patrick
Pfeffer, Martin
Naether, Philipp
Rodloff, Arne Christian
Meyer, Hermann
Two Distinct Clinical Courses of Human Cowpox, Germany, 2015
title Two Distinct Clinical Courses of Human Cowpox, Germany, 2015
title_full Two Distinct Clinical Courses of Human Cowpox, Germany, 2015
title_fullStr Two Distinct Clinical Courses of Human Cowpox, Germany, 2015
title_full_unstemmed Two Distinct Clinical Courses of Human Cowpox, Germany, 2015
title_short Two Distinct Clinical Courses of Human Cowpox, Germany, 2015
title_sort two distinct clinical courses of human cowpox, germany, 2015
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744150/
https://www.ncbi.nlm.nih.gov/pubmed/29215552
http://dx.doi.org/10.3390/v9120375
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