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Theory Meets Experiment: Metal Ion Effects in HCV Genomic RNA Kissing Complex Formation

The long-range base pairing between the 5BSL3. 2 and 3′X domains in hepatitis C virus (HCV) genomic RNA is essential for viral replication. Experimental evidence points to the critical role of metal ions, especially Mg(2+) ions, in the formation of the 5BSL3.2:3′X kissing complex. Furthermore, NMR s...

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Detalles Bibliográficos
Autores principales:	Sun, Li-Zhen, Heng, Xiao, Chen, Shi-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744182/ https://www.ncbi.nlm.nih.gov/pubmed/29312955 http://dx.doi.org/10.3389/fmolb.2017.00092

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