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The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans

The RNASEL –1385G/A (rs486907) variant has been reported to be associated with increased risk of prostate cancer. However, these associations are not consistent among studies. To address this issue, we performed a meta-analysis to evaluate the association between RNASEL –1385G/A polymorphism and pro...

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Autores principales: Liu, Xiaolei, Zheng, Dejie, Lu, Guowei, Yang, Baohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744743/
https://www.ncbi.nlm.nih.gov/pubmed/29317837
http://dx.doi.org/10.2147/OTT.S151398
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author Liu, Xiaolei
Zheng, Dejie
Lu, Guowei
Yang, Baohong
author_facet Liu, Xiaolei
Zheng, Dejie
Lu, Guowei
Yang, Baohong
author_sort Liu, Xiaolei
collection PubMed
description The RNASEL –1385G/A (rs486907) variant has been reported to be associated with increased risk of prostate cancer. However, these associations are not consistent among studies. To address this issue, we performed a meta-analysis to evaluate the association between RNASEL –1385G/A polymorphism and prostate cancer risk. The PubMed, Embase, and Web of Science databases were searched for relevant papers published in the past 20 years from 1997 to 2017. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. Based on our search for manuscripts reporting prostate cancer susceptibility related to the rs486907 polymorphism, 16 case–control studies from 13 different publications were retrieved. No significantly positive associations were found for the polymorphism and prostate cancer susceptibility in the total population. When stratified by ethnicity, the results demonstrated that the –1385G/A polymorphism was associated with a decreased cancer risk in Africans (GG vs AA: OR =0.371, 95% CI =0.176–0.783; GG/GA vs AA: OR =0.368, 95% CI =0.175–0.776). We also found that the rs486907 polymorphism was associated with a decreased cancer risk in hospital-based controls (GG vs AA: OR =0.697, 95% CI =0.488–0.996; GG + GA vs AA: OR =0.701, 95% CI =0.502–0.978). Our meta-analysis suggests that polymorphism in the RNASEL gene is a protective factor against prostate cancer in Africans. Further studies using larger sample sizes should be conducted to elucidate the role of gene polymorphism in prostate cancer risk.
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spelling pubmed-57447432018-01-09 The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans Liu, Xiaolei Zheng, Dejie Lu, Guowei Yang, Baohong Onco Targets Ther Review The RNASEL –1385G/A (rs486907) variant has been reported to be associated with increased risk of prostate cancer. However, these associations are not consistent among studies. To address this issue, we performed a meta-analysis to evaluate the association between RNASEL –1385G/A polymorphism and prostate cancer risk. The PubMed, Embase, and Web of Science databases were searched for relevant papers published in the past 20 years from 1997 to 2017. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. Based on our search for manuscripts reporting prostate cancer susceptibility related to the rs486907 polymorphism, 16 case–control studies from 13 different publications were retrieved. No significantly positive associations were found for the polymorphism and prostate cancer susceptibility in the total population. When stratified by ethnicity, the results demonstrated that the –1385G/A polymorphism was associated with a decreased cancer risk in Africans (GG vs AA: OR =0.371, 95% CI =0.176–0.783; GG/GA vs AA: OR =0.368, 95% CI =0.175–0.776). We also found that the rs486907 polymorphism was associated with a decreased cancer risk in hospital-based controls (GG vs AA: OR =0.697, 95% CI =0.488–0.996; GG + GA vs AA: OR =0.701, 95% CI =0.502–0.978). Our meta-analysis suggests that polymorphism in the RNASEL gene is a protective factor against prostate cancer in Africans. Further studies using larger sample sizes should be conducted to elucidate the role of gene polymorphism in prostate cancer risk. Dove Medical Press 2017-12-22 /pmc/articles/PMC5744743/ /pubmed/29317837 http://dx.doi.org/10.2147/OTT.S151398 Text en © 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Liu, Xiaolei
Zheng, Dejie
Lu, Guowei
Yang, Baohong
The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
title The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
title_full The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
title_fullStr The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
title_full_unstemmed The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
title_short The RNASEL –1385G/A polymorphism is associated with risk of prostate cancer in Africans
title_sort rnasel –1385g/a polymorphism is associated with risk of prostate cancer in africans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744743/
https://www.ncbi.nlm.nih.gov/pubmed/29317837
http://dx.doi.org/10.2147/OTT.S151398
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