Nuclear topology modulates the mutational landscapes of cancer genomes

Nuclear organization of genomic DNA affects DNA damage and repair processes, and yet its impact on mutational landscapes in cancer genomes remains unclear. Here we analyzed genome-wide somatic mutations from 366 samples of 6 cancer types. We found that lamina-associated regions, which are typically...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Kyle S., Liu, Lin L., Ganesan, Shridar, Michor, Franziska, De, Subhajyoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744871/
https://www.ncbi.nlm.nih.gov/pubmed/28967881
http://dx.doi.org/10.1038/nsmb.3474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744871/
https://www.ncbi.nlm.nih.gov/pubmed/28967881
http://dx.doi.org/10.1038/nsmb.3474

Ejemplares similares