4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

BACKGROUND: Chagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variable efficacy against different strains of the paras...

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Detalles Bibliográficos
Autores principales: Calvet, Claudia Magalhaes, Choi, Jun Yong, Thomas, Diane, Suzuki, Brian, Hirata, Ken, Lostracco-Johnson, Sharon, de Mesquita, Liliane Batista, Nogueira, Alanderson, Meuser-Batista, Marcelo, Silva, Tatiana Araujo, Siqueira-Neto, Jair Lage, Roush, William R., de Souza Pereira, Mirian Claudia, McKerrow, James H., Podust, Larissa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744913/
https://www.ncbi.nlm.nih.gov/pubmed/29281643
http://dx.doi.org/10.1371/journal.pntd.0006132

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