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Impaired PGE(2)-stimulated Cl(-) and HCO(3)(-) secretion contributes to cystic fibrosis airway disease

BACKGROUND: Airway mucociliary clearance (MCC) is an important defense mechanism against pulmonary infections and is compromised in cystic fibrosis (CF). Cl(-) and HCO(3)(-) epithelial transport are integral to MCC. During pulmonary infections prostaglandin E(2) (PGE(2)) production is abundant. AIM:...

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Detalles Bibliográficos
Autores principales:	Sellers, Zachary M., Illek, Beate, Figueira, Miriam Frankenthal, Hari, Gopika, Joo, Nam Soo, Sibley, Eric, Souza-Menezes, Jackson, Morales, Marcelo M., Fischer, Horst, Wine, Jeffrey J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744969/ https://www.ncbi.nlm.nih.gov/pubmed/29281691 http://dx.doi.org/10.1371/journal.pone.0189894

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