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Predicting apparent passive permeability of Caco-2 and MDCK cell-monolayers: A mechanistic model
Experimentally derived apparent permeabilities, P(app), through cell monolayers such as Caco-2 and MDCK are considered to be an in-vitro gold standard for assessing the uptake efficiency of drugs. Here, we present a mechanistic model that describes ‘passive’ P(app) values (i.e., neglecting active tr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744993/ https://www.ncbi.nlm.nih.gov/pubmed/29281711 http://dx.doi.org/10.1371/journal.pone.0190319 |