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Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model
Inflammation is a commonly observed immune reaction, and rheumatoid arthritis is a particularly severe inflammatory disease. In this study, we used an air pouch mouse model to evaluate the anti-inflammatory potential of Allium hookeri, which has both been used as a culinary material and a traditiona...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744995/ https://www.ncbi.nlm.nih.gov/pubmed/29281705 http://dx.doi.org/10.1371/journal.pone.0190305 |
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author | Kim, Jung-Eun Park, Kyung-Mok Lee, Soon-Young Seo, Ji-Hye Yoon, In-Soo Bae, Chun-Sik Yoo, Jin-Cheol Bang, Mi-Ae Cho, Seung-Sik Park, Dae-Hun |
author_facet | Kim, Jung-Eun Park, Kyung-Mok Lee, Soon-Young Seo, Ji-Hye Yoon, In-Soo Bae, Chun-Sik Yoo, Jin-Cheol Bang, Mi-Ae Cho, Seung-Sik Park, Dae-Hun |
author_sort | Kim, Jung-Eun |
collection | PubMed |
description | Inflammation is a commonly observed immune reaction, and rheumatoid arthritis is a particularly severe inflammatory disease. In this study, we used an air pouch mouse model to evaluate the anti-inflammatory potential of Allium hookeri, which has both been used as a culinary material and a traditional medicine in south-eastern Asia for many years. Allium hookeri suppressed typical symptoms of inflammation, such as condensation of the air pouch membrane, and inhibited the expression of several inducible proinflammatory cytokines such as IL-1β, IL-6, IL-13, and TNF-α. In order to determine the molecules modulating the inflammatory effect of carrageenan treatment, the components in Allium hookeri were analyzed by GC-MS, and linoleic acid, which have anti-inflammatory effect, was detected. From the results, we concluded that the anti-inflammatory effect of Allium hookeri might be attributed to linoleic acid, which could be promising candidates for anti-inflammatory drugs that have no adverse effects. |
format | Online Article Text |
id | pubmed-5744995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57449952018-01-09 Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model Kim, Jung-Eun Park, Kyung-Mok Lee, Soon-Young Seo, Ji-Hye Yoon, In-Soo Bae, Chun-Sik Yoo, Jin-Cheol Bang, Mi-Ae Cho, Seung-Sik Park, Dae-Hun PLoS One Research Article Inflammation is a commonly observed immune reaction, and rheumatoid arthritis is a particularly severe inflammatory disease. In this study, we used an air pouch mouse model to evaluate the anti-inflammatory potential of Allium hookeri, which has both been used as a culinary material and a traditional medicine in south-eastern Asia for many years. Allium hookeri suppressed typical symptoms of inflammation, such as condensation of the air pouch membrane, and inhibited the expression of several inducible proinflammatory cytokines such as IL-1β, IL-6, IL-13, and TNF-α. In order to determine the molecules modulating the inflammatory effect of carrageenan treatment, the components in Allium hookeri were analyzed by GC-MS, and linoleic acid, which have anti-inflammatory effect, was detected. From the results, we concluded that the anti-inflammatory effect of Allium hookeri might be attributed to linoleic acid, which could be promising candidates for anti-inflammatory drugs that have no adverse effects. Public Library of Science 2017-12-27 /pmc/articles/PMC5744995/ /pubmed/29281705 http://dx.doi.org/10.1371/journal.pone.0190305 Text en © 2017 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Jung-Eun Park, Kyung-Mok Lee, Soon-Young Seo, Ji-Hye Yoon, In-Soo Bae, Chun-Sik Yoo, Jin-Cheol Bang, Mi-Ae Cho, Seung-Sik Park, Dae-Hun Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model |
title | Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model |
title_full | Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model |
title_fullStr | Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model |
title_full_unstemmed | Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model |
title_short | Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model |
title_sort | anti-inflammatory effect of allium hookeri on carrageenan-induced air pouch mouse model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744995/ https://www.ncbi.nlm.nih.gov/pubmed/29281705 http://dx.doi.org/10.1371/journal.pone.0190305 |
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