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Atomic view of the energy landscape in the allosteric regulation of Abl kinase
The activity of protein kinases is often regulated in an intramolecular fashion by signaling domains, which feature several phosphorylation or protein-docking sites. How kinases integrate such distinct binding and signaling events to regulate their activities is unclear, especially in quantitative t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745040/ https://www.ncbi.nlm.nih.gov/pubmed/28945248 http://dx.doi.org/10.1038/nsmb.3470 |