Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S tau mice. Biochemical fractionation shows co-...

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Detalles Bibliográficos
Autores principales: Apicco, Daniel J., Ash, Peter E. A., Maziuk, Brandon, LeBlang, Chelsey, Medalla, Maria, Abdullatif, Ali Al, Ferragud, Antonio, Botelho, Emily, Ballance, Heather I., Dhawan, Uma, Boudeau, Samantha, Cruz, Anna Lourdes, Kashy, Daniel, Wong, Aria, Goldberg, Lisa R., Yazdani, Neema, Zhang, Cheng, Ung, Choong Y, Tripodis, Yorghos, Kanaan, Nicholas M., Ikezu, Tsuneya, Cottone, Pietro, Leszyk, John, Li, Hu, Luebke, Jennifer, Bryant, Camron D., Wolozin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745051/
https://www.ncbi.nlm.nih.gov/pubmed/29273772
http://dx.doi.org/10.1038/s41593-017-0022-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745051/
https://www.ncbi.nlm.nih.gov/pubmed/29273772
http://dx.doi.org/10.1038/s41593-017-0022-z

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