Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load

Enzootic bovine leukemia is caused by the bovine leukemia virus (BLV). BLV is transmitted vertically or horizontally through the transfer of infected cells via direct contact, through milk, insect bites and contaminated iatrogenic procedures. However, we lacked direct evidence of intrauterine infect...

Descripción completa

Detalles Bibliográficos
Autores principales: SAJIKI, Yamato, KONNAI, Satoru, NISHIMORI, Asami, OKAGAWA, Tomohiro, MAEKAWA, Naoya, GOTO, Shinya, NAGANO, Masashi, KOHARA, Junko, KITANO, Nana, TAKAHASHI, Toshihiko, TAJIMA, Motoshi, MEKATA, Hirohisa, HORII, Yoichiro, MURATA, Shiro, OHASHI, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745186/
https://www.ncbi.nlm.nih.gov/pubmed/29109356
http://dx.doi.org/10.1292/jvms.17-0391
Descripción
Sumario:Enzootic bovine leukemia is caused by the bovine leukemia virus (BLV). BLV is transmitted vertically or horizontally through the transfer of infected cells via direct contact, through milk, insect bites and contaminated iatrogenic procedures. However, we lacked direct evidence of intrauterine infection. The purpose of this study was to confirm intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery. BLV was detected in cord and placental blood, and the BLV in the newborns showed 100% nucleotide identity with the BLV-env sequence from the dams. Notably, a newborn was seropositive for BLV but had no colostral antibodies. In this study, we presented a direct evidence of intrauterine BLV transmission in pregnant dam with a high proviral load. These results could aid the development of BLV control measures targeting viral load.

Ejemplares similares