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Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack

BACKGROUND: The implications of early readmission on long‐term mortality after transient ischemic attack (TIA) are not known. We aimed at examining the effect of 180‐day readmission on subsequent long‐term mortality after index hospitalization for TIA. METHODS: A retrospective study of patients hosp...

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Autores principales: Yousufuddin, Mohammed, Young, Nathan, Keenan, Lawrence, Olson, Tammy, Shultz, Jessica, Doyle, Taylor, Ahmmad, Eimad, Arumaithurai, Kogulavadanan, Takahashi, Paul, Murad, Mohammad Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745244/
https://www.ncbi.nlm.nih.gov/pubmed/29299384
http://dx.doi.org/10.1002/brb3.865
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author Yousufuddin, Mohammed
Young, Nathan
Keenan, Lawrence
Olson, Tammy
Shultz, Jessica
Doyle, Taylor
Ahmmad, Eimad
Arumaithurai, Kogulavadanan
Takahashi, Paul
Murad, Mohammad Hassan
author_facet Yousufuddin, Mohammed
Young, Nathan
Keenan, Lawrence
Olson, Tammy
Shultz, Jessica
Doyle, Taylor
Ahmmad, Eimad
Arumaithurai, Kogulavadanan
Takahashi, Paul
Murad, Mohammad Hassan
author_sort Yousufuddin, Mohammed
collection PubMed
description BACKGROUND: The implications of early readmission on long‐term mortality after transient ischemic attack (TIA) are not known. We aimed at examining the effect of 180‐day readmission on subsequent long‐term mortality after index hospitalization for TIA. METHODS: A retrospective study of patients hospitalized for first‐ever TIA at Mayo Clinic from 2000 through 2017. Patients readmitted within 180 days postdischarge were compared with those not readmitted in long‐term risk of death. RESULTS: Of 251 TIA patients aged 73 ± 15 years with 1509 person‐years of follow‐up, 65 (26%) were readmitted within 180 days of discharge and 125 died during a median follow‐up of 5.7 years. The mortality was 10 vs. 7 deaths per 100 person‐years in patients who were readmitted compared to those who were not readmitted with hazard ratio (HR) 1.73 (95% confidence interval [CI] 1.13–2.66). Other competing predictors of mortality were age ≥65 years (HR 5.70, 95% CI 2.72–11.96), cancer (HR 1.65, 95% CI 1.03–3.38), chronic obstructive pulmonary disease (HR 1.90, 95% CI 1.07–3.38), heart failure (HR 3.03, 95% CI 1.82–5.06), dementia (HR 5.87, 95% CI 3.27–10.52), creatinine ≥1.4 mg/dl (HR 1.89, 95% CI 1.17–3.06), and hemoglobin level <10 g/dl (HR 2.80, 95% CI 1.20–6.66). CONCLUSIONS: Hospital readmission within 180 days of discharge from index TIA was associated with increased risk of death several years after initial readmission. Older age and several comorbidities identified during index hospitalization also confer increased risk for long‐term mortality.
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spelling pubmed-57452442018-01-03 Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack Yousufuddin, Mohammed Young, Nathan Keenan, Lawrence Olson, Tammy Shultz, Jessica Doyle, Taylor Ahmmad, Eimad Arumaithurai, Kogulavadanan Takahashi, Paul Murad, Mohammad Hassan Brain Behav Original Research BACKGROUND: The implications of early readmission on long‐term mortality after transient ischemic attack (TIA) are not known. We aimed at examining the effect of 180‐day readmission on subsequent long‐term mortality after index hospitalization for TIA. METHODS: A retrospective study of patients hospitalized for first‐ever TIA at Mayo Clinic from 2000 through 2017. Patients readmitted within 180 days postdischarge were compared with those not readmitted in long‐term risk of death. RESULTS: Of 251 TIA patients aged 73 ± 15 years with 1509 person‐years of follow‐up, 65 (26%) were readmitted within 180 days of discharge and 125 died during a median follow‐up of 5.7 years. The mortality was 10 vs. 7 deaths per 100 person‐years in patients who were readmitted compared to those who were not readmitted with hazard ratio (HR) 1.73 (95% confidence interval [CI] 1.13–2.66). Other competing predictors of mortality were age ≥65 years (HR 5.70, 95% CI 2.72–11.96), cancer (HR 1.65, 95% CI 1.03–3.38), chronic obstructive pulmonary disease (HR 1.90, 95% CI 1.07–3.38), heart failure (HR 3.03, 95% CI 1.82–5.06), dementia (HR 5.87, 95% CI 3.27–10.52), creatinine ≥1.4 mg/dl (HR 1.89, 95% CI 1.17–3.06), and hemoglobin level <10 g/dl (HR 2.80, 95% CI 1.20–6.66). CONCLUSIONS: Hospital readmission within 180 days of discharge from index TIA was associated with increased risk of death several years after initial readmission. Older age and several comorbidities identified during index hospitalization also confer increased risk for long‐term mortality. John Wiley and Sons Inc. 2017-11-22 /pmc/articles/PMC5745244/ /pubmed/29299384 http://dx.doi.org/10.1002/brb3.865 Text en © 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Yousufuddin, Mohammed
Young, Nathan
Keenan, Lawrence
Olson, Tammy
Shultz, Jessica
Doyle, Taylor
Ahmmad, Eimad
Arumaithurai, Kogulavadanan
Takahashi, Paul
Murad, Mohammad Hassan
Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
title Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
title_full Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
title_fullStr Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
title_full_unstemmed Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
title_short Effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
title_sort effect of early hospital readmission and comorbid conditions on subsequent long‐term mortality after transient ischemic attack
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745244/
https://www.ncbi.nlm.nih.gov/pubmed/29299384
http://dx.doi.org/10.1002/brb3.865
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