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Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients

We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. P...

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Autores principales: Huysse, Wouter, Lecouvet, Frédéric, Castellucci, Paolo, Ost, Piet, Lambrecht, Valerie, Artigas, Carlos, Denis, Marie-Laurence, De Man, Kathia, Delrue, Louke, Jans, Lennart, De Bruycker, Aurélie, De Vos, Filip, De Meerleer, Gert, Decaestecker, Karel, Fonteyne, Valerie, Lambert, Bieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745392/
https://www.ncbi.nlm.nih.gov/pubmed/29039785
http://dx.doi.org/10.3390/diagnostics7040056
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author Huysse, Wouter
Lecouvet, Frédéric
Castellucci, Paolo
Ost, Piet
Lambrecht, Valerie
Artigas, Carlos
Denis, Marie-Laurence
De Man, Kathia
Delrue, Louke
Jans, Lennart
De Bruycker, Aurélie
De Vos, Filip
De Meerleer, Gert
Decaestecker, Karel
Fonteyne, Valerie
Lambert, Bieke
author_facet Huysse, Wouter
Lecouvet, Frédéric
Castellucci, Paolo
Ost, Piet
Lambrecht, Valerie
Artigas, Carlos
Denis, Marie-Laurence
De Man, Kathia
Delrue, Louke
Jans, Lennart
De Bruycker, Aurélie
De Vos, Filip
De Meerleer, Gert
Decaestecker, Karel
Fonteyne, Valerie
Lambert, Bieke
author_sort Huysse, Wouter
collection PubMed
description We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3–4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading. The best valuable comparator (BVC) defined the metastatic status. On the basis of the BVC, 15 out of 64 patients presented with 24 bone metastases. On a patient level, the sensitivity and specificity of MRI and PET were not significantly different. On a lesion level, the sensitivity of MRI was significantly better compared to PET, and the specificity did not differ significantly. In conclusion, axial MRI is an interesting screening tool for the detection of bone metastases because of its low probability of false negative results. However, F-18 choline PET is a valuable addition as it can overrule false positive MRI results and detect non-axial metastases.
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spelling pubmed-57453922018-01-02 Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients Huysse, Wouter Lecouvet, Frédéric Castellucci, Paolo Ost, Piet Lambrecht, Valerie Artigas, Carlos Denis, Marie-Laurence De Man, Kathia Delrue, Louke Jans, Lennart De Bruycker, Aurélie De Vos, Filip De Meerleer, Gert Decaestecker, Karel Fonteyne, Valerie Lambert, Bieke Diagnostics (Basel) Article We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3–4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading. The best valuable comparator (BVC) defined the metastatic status. On the basis of the BVC, 15 out of 64 patients presented with 24 bone metastases. On a patient level, the sensitivity and specificity of MRI and PET were not significantly different. On a lesion level, the sensitivity of MRI was significantly better compared to PET, and the specificity did not differ significantly. In conclusion, axial MRI is an interesting screening tool for the detection of bone metastases because of its low probability of false negative results. However, F-18 choline PET is a valuable addition as it can overrule false positive MRI results and detect non-axial metastases. MDPI 2017-10-17 /pmc/articles/PMC5745392/ /pubmed/29039785 http://dx.doi.org/10.3390/diagnostics7040056 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huysse, Wouter
Lecouvet, Frédéric
Castellucci, Paolo
Ost, Piet
Lambrecht, Valerie
Artigas, Carlos
Denis, Marie-Laurence
De Man, Kathia
Delrue, Louke
Jans, Lennart
De Bruycker, Aurélie
De Vos, Filip
De Meerleer, Gert
Decaestecker, Karel
Fonteyne, Valerie
Lambert, Bieke
Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients
title Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients
title_full Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients
title_fullStr Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients
title_full_unstemmed Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients
title_short Prospective Comparison of F-18 Choline PET/CT Scan Versus Axial MRI for Detecting Bone Metastasis in Biochemically Relapsed Prostate Cancer Patients
title_sort prospective comparison of f-18 choline pet/ct scan versus axial mri for detecting bone metastasis in biochemically relapsed prostate cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745392/
https://www.ncbi.nlm.nih.gov/pubmed/29039785
http://dx.doi.org/10.3390/diagnostics7040056
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