Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells

We previously reported that raloxifene, an estrogen receptor modulator, is also a ligand for the aryl hydrocarbon receptor (AhR). Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR. We performed structure–activity studies with seven raloxifene analogs to be...

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Detalles Bibliográficos
Autores principales: Jang, Hyo Sang, Pearce, Martin, O’Donnell, Edmond F., Nguyen, Bach Duc, Truong, Lisa, Mueller, Monica J., Bisson, William H., Kerkvliet, Nancy I., Tanguay, Robert L., Kolluri, Siva Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745446/
https://www.ncbi.nlm.nih.gov/pubmed/29194351
http://dx.doi.org/10.3390/biology6040041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745446/
https://www.ncbi.nlm.nih.gov/pubmed/29194351
http://dx.doi.org/10.3390/biology6040041

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