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Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health
Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745462/ https://www.ncbi.nlm.nih.gov/pubmed/29206168 http://dx.doi.org/10.3390/biom7040080 |
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author | Khurshid, Zohaib Naseem, Mustafa Yahya I. Asiri, Faris Mali, Maria Sannam Khan, Rabia Sahibzada, Haafsa Arshad Zafar, Muhammad Sohail Faraz Moin, Syed Khan, Erum |
author_facet | Khurshid, Zohaib Naseem, Mustafa Yahya I. Asiri, Faris Mali, Maria Sannam Khan, Rabia Sahibzada, Haafsa Arshad Zafar, Muhammad Sohail Faraz Moin, Syed Khan, Erum |
author_sort | Khurshid, Zohaib |
collection | PubMed |
description | Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity. Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. Living in the era where the major focus is on non-invasive and nanotechnology, this ultimately leads to further advancements in the field of salivaomics. Based on current spotlight innovations, we have highlighted the biochemistry, mode of action, and the importance of cathelicidins in the oral cavity. |
format | Online Article Text |
id | pubmed-5745462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57454622018-01-02 Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health Khurshid, Zohaib Naseem, Mustafa Yahya I. Asiri, Faris Mali, Maria Sannam Khan, Rabia Sahibzada, Haafsa Arshad Zafar, Muhammad Sohail Faraz Moin, Syed Khan, Erum Biomolecules Review Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity. Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. Living in the era where the major focus is on non-invasive and nanotechnology, this ultimately leads to further advancements in the field of salivaomics. Based on current spotlight innovations, we have highlighted the biochemistry, mode of action, and the importance of cathelicidins in the oral cavity. MDPI 2017-12-05 /pmc/articles/PMC5745462/ /pubmed/29206168 http://dx.doi.org/10.3390/biom7040080 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khurshid, Zohaib Naseem, Mustafa Yahya I. Asiri, Faris Mali, Maria Sannam Khan, Rabia Sahibzada, Haafsa Arshad Zafar, Muhammad Sohail Faraz Moin, Syed Khan, Erum Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health |
title | Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health |
title_full | Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health |
title_fullStr | Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health |
title_full_unstemmed | Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health |
title_short | Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health |
title_sort | significance and diagnostic role of antimicrobial cathelicidins (ll-37) peptides in oral health |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745462/ https://www.ncbi.nlm.nih.gov/pubmed/29206168 http://dx.doi.org/10.3390/biom7040080 |
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