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Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii

Acinetobacter baumannii is an important opportunistic nosocomial pathogen often resistant to multiple antibiotics classes. Colistin, an “old” antibiotic, is now considered a last-line treatment option for extremely resistant isolates. In the meantime, resistance to colistin has been reported in clin...

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Autores principales: Da Silva, Gabriela Jorge, Domingues, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745471/
https://www.ncbi.nlm.nih.gov/pubmed/29160808
http://dx.doi.org/10.3390/antibiotics6040028
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author Da Silva, Gabriela Jorge
Domingues, Sara
author_facet Da Silva, Gabriela Jorge
Domingues, Sara
author_sort Da Silva, Gabriela Jorge
collection PubMed
description Acinetobacter baumannii is an important opportunistic nosocomial pathogen often resistant to multiple antibiotics classes. Colistin, an “old” antibiotic, is now considered a last-line treatment option for extremely resistant isolates. In the meantime, resistance to colistin has been reported in clinical A. baumannii strains. Colistin is a cationic peptide that disrupts the outer membrane (OM) of Gram-negative bacteria. Colistin resistance is primarily due to post-translational modification or loss of the lipopolysaccharide (LPS) molecules inserted into the outer leaflet of the OM. LPS modification prevents the binding of polymyxin to the bacterial surface and may lead to alterations in bacterial virulence. Antimicrobial pressure drives the evolution of antimicrobial resistance and resistance is often associated with a reduced bacterial fitness. Therefore, the alterations in LPS may induce changes in the fitness of A. baumannii. However, compensatory mutations in clinical A. baumannii may ameliorate the cost of resistance and may play an important role in the dissemination of colistin-resistant A. baumannii isolates. The focus of this review is to summarize the colistin resistance mechanisms, and understand their impact on the fitness and virulence of bacteria and on the dissemination of colistin-resistant A. baumannii strains.
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spelling pubmed-57454712018-01-02 Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii Da Silva, Gabriela Jorge Domingues, Sara Antibiotics (Basel) Review Acinetobacter baumannii is an important opportunistic nosocomial pathogen often resistant to multiple antibiotics classes. Colistin, an “old” antibiotic, is now considered a last-line treatment option for extremely resistant isolates. In the meantime, resistance to colistin has been reported in clinical A. baumannii strains. Colistin is a cationic peptide that disrupts the outer membrane (OM) of Gram-negative bacteria. Colistin resistance is primarily due to post-translational modification or loss of the lipopolysaccharide (LPS) molecules inserted into the outer leaflet of the OM. LPS modification prevents the binding of polymyxin to the bacterial surface and may lead to alterations in bacterial virulence. Antimicrobial pressure drives the evolution of antimicrobial resistance and resistance is often associated with a reduced bacterial fitness. Therefore, the alterations in LPS may induce changes in the fitness of A. baumannii. However, compensatory mutations in clinical A. baumannii may ameliorate the cost of resistance and may play an important role in the dissemination of colistin-resistant A. baumannii isolates. The focus of this review is to summarize the colistin resistance mechanisms, and understand their impact on the fitness and virulence of bacteria and on the dissemination of colistin-resistant A. baumannii strains. MDPI 2017-11-21 /pmc/articles/PMC5745471/ /pubmed/29160808 http://dx.doi.org/10.3390/antibiotics6040028 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Da Silva, Gabriela Jorge
Domingues, Sara
Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii
title Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii
title_full Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii
title_fullStr Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii
title_full_unstemmed Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii
title_short Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii
title_sort interplay between colistin resistance, virulence and fitness in acinetobacter baumannii
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745471/
https://www.ncbi.nlm.nih.gov/pubmed/29160808
http://dx.doi.org/10.3390/antibiotics6040028
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