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Tocotrienols: A Family of Molecules with Specific Biological Activities
Vitamin E is a generic term frequently used to group together eight different molecules, namely: α-, β-, γ- and δ-tocopherol and the corresponding tocotrienols. The term tocopherol and eventually Vitamin E and its related activity was originally based on the capacity of countering foetal re-absorpti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745503/ https://www.ncbi.nlm.nih.gov/pubmed/29156559 http://dx.doi.org/10.3390/antiox6040093 |
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author | Comitato, Raffaella Ambra, Roberto Virgili, Fabio |
author_facet | Comitato, Raffaella Ambra, Roberto Virgili, Fabio |
author_sort | Comitato, Raffaella |
collection | PubMed |
description | Vitamin E is a generic term frequently used to group together eight different molecules, namely: α-, β-, γ- and δ-tocopherol and the corresponding tocotrienols. The term tocopherol and eventually Vitamin E and its related activity was originally based on the capacity of countering foetal re-absorption in deficient rodents or the development of encephalomalacia in chickens. In humans, Vitamin E activity is generally considered to be solely related to the antioxidant properties of the tocolic chemical structure. In recent years, several reports have shown that specific activities exist for each different tocotrienol form. In this short review, tocotrienol ability to inhibit cancer cell growth and induce apoptosis thanks to specific mechanisms, not shared by tocopherols, such as the binding to Estrogen Receptor-β (ERβ) and the triggering of endoplasmic reticulum (EndoR) stress will be described. The neuroprotective activity will also be presented and discussed. We propose that available studies strongly indicate that specific forms of tocotrienols have a distinct mechanism and biological activity, significantly different from tocopherol and more specifically from α-tocopherol. We therefore suggest not pooling them together within the broad term “Vitamin E” on solely the basis of their putative antioxidant properties. This option implies obvious consequences in the assessment of dietary Vitamin E adequacy and, probably more importantly, on the possibility of evaluating a separate biological variable, determinant in the relationship between diet and health. |
format | Online Article Text |
id | pubmed-5745503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57455032018-01-02 Tocotrienols: A Family of Molecules with Specific Biological Activities Comitato, Raffaella Ambra, Roberto Virgili, Fabio Antioxidants (Basel) Review Vitamin E is a generic term frequently used to group together eight different molecules, namely: α-, β-, γ- and δ-tocopherol and the corresponding tocotrienols. The term tocopherol and eventually Vitamin E and its related activity was originally based on the capacity of countering foetal re-absorption in deficient rodents or the development of encephalomalacia in chickens. In humans, Vitamin E activity is generally considered to be solely related to the antioxidant properties of the tocolic chemical structure. In recent years, several reports have shown that specific activities exist for each different tocotrienol form. In this short review, tocotrienol ability to inhibit cancer cell growth and induce apoptosis thanks to specific mechanisms, not shared by tocopherols, such as the binding to Estrogen Receptor-β (ERβ) and the triggering of endoplasmic reticulum (EndoR) stress will be described. The neuroprotective activity will also be presented and discussed. We propose that available studies strongly indicate that specific forms of tocotrienols have a distinct mechanism and biological activity, significantly different from tocopherol and more specifically from α-tocopherol. We therefore suggest not pooling them together within the broad term “Vitamin E” on solely the basis of their putative antioxidant properties. This option implies obvious consequences in the assessment of dietary Vitamin E adequacy and, probably more importantly, on the possibility of evaluating a separate biological variable, determinant in the relationship between diet and health. MDPI 2017-11-18 /pmc/articles/PMC5745503/ /pubmed/29156559 http://dx.doi.org/10.3390/antiox6040093 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Comitato, Raffaella Ambra, Roberto Virgili, Fabio Tocotrienols: A Family of Molecules with Specific Biological Activities |
title | Tocotrienols: A Family of Molecules with Specific Biological Activities |
title_full | Tocotrienols: A Family of Molecules with Specific Biological Activities |
title_fullStr | Tocotrienols: A Family of Molecules with Specific Biological Activities |
title_full_unstemmed | Tocotrienols: A Family of Molecules with Specific Biological Activities |
title_short | Tocotrienols: A Family of Molecules with Specific Biological Activities |
title_sort | tocotrienols: a family of molecules with specific biological activities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745503/ https://www.ncbi.nlm.nih.gov/pubmed/29156559 http://dx.doi.org/10.3390/antiox6040093 |
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