Cargando…

Tempol Supplementation Restores Diaphragm Force and Metabolic Enzyme Activities in mdx Mice

Duchenne muscular dystrophy (DMD) is characterized by striated muscle weakness, cardiomyopathy, and respiratory failure. Since oxidative stress is recognized as a secondary pathology in DMD, the efficacy of antioxidant intervention, using the superoxide scavenger tempol, was examined on functional a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burns, David P., Ali, Izza, Rieux, Clement, Healy, James, Jasionek, Greg, O’Halloran, Ken D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745511/ https://www.ncbi.nlm.nih.gov/pubmed/29210997 http://dx.doi.org/10.3390/antiox6040101

Ejemplares similares

N-acetylcysteine Decreases Fibrosis and Increases Force-Generating Capacity of mdx Diaphragm
por: Burns, David P., et al.
Publicado: (2019)

Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained-mdx Mice
por: da Silva, Heloina Nathalliê Mariano, et al.
Publicado: (2021)

Tempol treatment shows phenotype improvement in mdx mice
por: Hermes, Túlio de Almeida, et al.
Publicado: (2019)

Proteome Profiling of the Dystrophic mdx Mice Diaphragm
por: Mucha, Olga, et al.
Publicado: (2023)

Chronic Intermittent Hypoxia-Induced Diaphragm Muscle Weakness Is NADPH Oxidase-2 Dependent
por: Drummond, Sarah E., et al.
Publicado: (2023)

Restoration of Endothelial Function in Pparα (−/−) Mice by Tempol
por: Silswal, Neerupma, et al.
Publicado: (2015)

Aquaporin 4 Expression in the mdx Mouse Diaphragm
por: Hara, Hajime, et al.
Publicado: (2011)

Dystrophic phenotype improvement in the diaphragm muscle of mdx mice by diacerhein
por: Mâncio, Rafael Dias, et al.
Publicado: (2017)

Muscle reorganisation through local injection of stem cells in the diaphragm of mdx mice
por: Lessa, Thais Borges, et al.
Publicado: (2012)

Diaphragm Muscle Adaptation to Sustained Hypoxia: Lessons from Animal Models with Relevance to High Altitude and Chronic Respiratory Diseases
por: Lewis, Philip, et al.
Publicado: (2016)

Impact of estrogen deficiency on diaphragm and leg muscle contractile function in female mdx mice
por: Vang, Pangdra, et al.
Publicado: (2021)

Myofibrillar Lattice Remodeling Is a Structural Cytoskeletal Predictor of Diaphragm Muscle Weakness in a Fibrotic mdx (mdx Cmah(−/−)) Model
por: Ritter, Paul, et al.
Publicado: (2022)

Effects of Gestational and Postnatal Exposure to Chronic Intermittent Hypoxia on Diaphragm Muscle Contractile Function in the Rat
por: McDonald, Fiona B., et al.
Publicado: (2016)

Curcumin Administration Improves Force of mdx Dystrophic Diaphragm by Acting on Fiber-Type Composition, Myosin Nitrotyrosination and SERCA1 Protein Levels
por: Gorza, Luisa, et al.
Publicado: (2023)

TEMPOL increases NAD(+) and improves redox imbalance in obese mice
por: Yamato, Mayumi, et al.
Publicado: (2016)

Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine
por: O'Leary, Andrew J., et al.
Publicado: (2018)

Tempol Treatment of Covid-19
por: Proctor, Peter
Publicado: (2020)

Muscle gene electrotransfer is increased by the antioxidant tempol in mice
por: Markelc, B, et al.
Publicado: (2012)

Tempol intake improves inflammatory status in aged mice
por: Yamato, Mayumi, et al.
Publicado: (2014)

Ultrasonography validation for early alteration of diaphragm echodensity and function in the mdx mouse model of Duchenne muscular dystrophy
por: Mele, Antonietta, et al.
Publicado: (2021)

Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy
por: Dowling, Paul, et al.
Publicado: (2023)

Tempol differently affects cellular redox changes and antioxidant enzymes in various lung-related cells
por: Park, Woo Hyun
Publicado: (2021)

NADPH oxidase 2 is necessary for chronic intermittent hypoxia‐induced sternohyoid muscle weakness in adult male mice
por: Drummond, Sarah E., et al.
Publicado: (2022)

Antioxidant properties of MitoTEMPOL and its hydroxylamine
por: Trnka, Jan, et al.
Publicado: (2008)

Tempol effects on diabetic nephropathy in male rats
por: Ranjbar, Akram, et al.
Publicado: (2016)

Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle
por: Roy, Pauline, et al.
Publicado: (2016)

Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice
por: Desjardins, Cody A, et al.
Publicado: (2022)

Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes
por: Casini, S, et al.
Publicado: (2023)

Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol
por: Mishra, Paras K, et al.
Publicado: (2010)

Tempol effect on epithelial-mesenchymal transition induced by hyperglycemia
por: Jafari, Mohammad, et al.
Publicado: (2017)

Protective Effect of Tempol against Cisplatin-Induced Ototoxicity
por: Youn, Cha Kyung, et al.
Publicado: (2016)

Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice
por: Sebori, Rio, et al.
Publicado: (2018)

Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy
por: CARBERRY, STEVEN, et al.
Publicado: (2012)

Supplementation with a selective amino acid formula ameliorates muscular dystrophy in mdx mice
por: Banfi, Stefania, et al.
Publicado: (2018)

Normal myogenic cells from newborn mice restore normal histology to degenerating muscles of the mdx mouse
Publicado: (1990)

Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles
por: McRae, Natasha L., et al.
Publicado: (2020)

Stable Redox-Cycling Nitroxide Tempol Inhibits NET Formation
por: Hosseinzadeh, Ava, et al.
Publicado: (2012)

Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production
por: Jia, Donglin, et al.
Publicado: (2019)

Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl
por: Baby, Santhosh, et al.
Publicado: (2021)

Superoxide dismutase analog (TEMPOL: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence
por: Kawakami, Toshifumi, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_6bsuiav1rte776rdj8tkdl4ra5