PDK4 Deficiency Induces Intrinsic Apoptosis in Response to Starvation in Fibroblasts from Doberman Pinschers with Dilated Cardiomyopathy

The Doberman pinscher (DP) canine breed displays a high incidence of idiopathic, nonischemic dilated cardiomyopathy (DCM) with increased mortality. A common mutation in DPs is a splice site deletion in the pyruvate dehydrogenase kinase 4 (PDK4) gene that shows a positive correlation with DCM develop...

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Detalles Bibliográficos
Autores principales: Taggart, Kathryn, Estrada, Amara, Thompson, Patrick, Lourenco, Francisco, Kirmani, Sara, Suzuki-Hatano, Silveli, Pacak, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745584/
https://www.ncbi.nlm.nih.gov/pubmed/29285418
http://dx.doi.org/10.1089/biores.2017.0023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745584/
https://www.ncbi.nlm.nih.gov/pubmed/29285418
http://dx.doi.org/10.1089/biores.2017.0023

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