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Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review
BACKGROUND: The obesity prevalence in children and adolescents has increased worldwide during the past 30 years. Although diet has been identified as one risk factor for developing obesity in this age group, the role of specific dietary factors is still unclear. One way to gain insight into the role...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745631/ https://www.ncbi.nlm.nih.gov/pubmed/29282082 http://dx.doi.org/10.1186/s12937-017-0300-3 |
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author | Hilger-Kolb, Jennifer Bosle, Catherin Motoc, Irina Hoffmann, Kristina |
author_facet | Hilger-Kolb, Jennifer Bosle, Catherin Motoc, Irina Hoffmann, Kristina |
author_sort | Hilger-Kolb, Jennifer |
collection | PubMed |
description | BACKGROUND: The obesity prevalence in children and adolescents has increased worldwide during the past 30 years. Although diet has been identified as one risk factor for developing obesity in this age group, the role of specific dietary factors is still unclear. One way to gain insight into the role of these factors might be to detect biomarkers that reflect metabolic health and to identify the associations between dietary factors and these biomarkers. This would enable nutrition-related metabolic changes to be detected early in life, which might be a promising strategy to prevent childhood obesity. However, existing literature offers only inconclusive evidence for diet and some of these obesity-related biomarkers (e.g., blood lipids). We thus conducted a systematic literature review to further examine eligible studies that investigate associations between dietary factors and 12 obesity-related biomarkers in healthy children and adolescents aged 3-18 years. METHODS: We searched the scientific databases PubMed/Medline and Web of Science Core Collection for potentially eligible articles. Our final literature search resulted in 2727 hits. After the selection process, we included 81 articles that reported on 1111 single observations on dietary factors and any of the obesity-related biomarkers. RESULTS: Around 81% of the total observations showed nonsignificant results. For many biomarkers we did not find enough observations to draw clear conclusions on possible associations between a dietary factor and the respective biomarker. In cases where we identified enough observations, the results were contradictory. Since these nonsignificant and inconclusive findings may impede the development of effective strategies against childhood obesity, this article takes a closer look at possible reasons for such findings. In addition, it provides action points for future research efforts. CONCLUSIONS: In conclusion, current evidence on associations between dietary factors and obesity-related biomarkers is inconclusive. We thus provided an overview on which specific limitations may impede current research. Such knowledge is necessary to enable future research efforts to better elucidate the role of diet in the early stages of obesity development. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12937-017-0300-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5745631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57456312018-01-03 Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review Hilger-Kolb, Jennifer Bosle, Catherin Motoc, Irina Hoffmann, Kristina Nutr J Review BACKGROUND: The obesity prevalence in children and adolescents has increased worldwide during the past 30 years. Although diet has been identified as one risk factor for developing obesity in this age group, the role of specific dietary factors is still unclear. One way to gain insight into the role of these factors might be to detect biomarkers that reflect metabolic health and to identify the associations between dietary factors and these biomarkers. This would enable nutrition-related metabolic changes to be detected early in life, which might be a promising strategy to prevent childhood obesity. However, existing literature offers only inconclusive evidence for diet and some of these obesity-related biomarkers (e.g., blood lipids). We thus conducted a systematic literature review to further examine eligible studies that investigate associations between dietary factors and 12 obesity-related biomarkers in healthy children and adolescents aged 3-18 years. METHODS: We searched the scientific databases PubMed/Medline and Web of Science Core Collection for potentially eligible articles. Our final literature search resulted in 2727 hits. After the selection process, we included 81 articles that reported on 1111 single observations on dietary factors and any of the obesity-related biomarkers. RESULTS: Around 81% of the total observations showed nonsignificant results. For many biomarkers we did not find enough observations to draw clear conclusions on possible associations between a dietary factor and the respective biomarker. In cases where we identified enough observations, the results were contradictory. Since these nonsignificant and inconclusive findings may impede the development of effective strategies against childhood obesity, this article takes a closer look at possible reasons for such findings. In addition, it provides action points for future research efforts. CONCLUSIONS: In conclusion, current evidence on associations between dietary factors and obesity-related biomarkers is inconclusive. We thus provided an overview on which specific limitations may impede current research. Such knowledge is necessary to enable future research efforts to better elucidate the role of diet in the early stages of obesity development. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12937-017-0300-3) contains supplementary material, which is available to authorized users. BioMed Central 2017-12-28 /pmc/articles/PMC5745631/ /pubmed/29282082 http://dx.doi.org/10.1186/s12937-017-0300-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Hilger-Kolb, Jennifer Bosle, Catherin Motoc, Irina Hoffmann, Kristina Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
title | Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
title_full | Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
title_fullStr | Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
title_full_unstemmed | Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
title_short | Associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
title_sort | associations between dietary factors and obesity-related biomarkers in healthy children and adolescents - a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745631/ https://www.ncbi.nlm.nih.gov/pubmed/29282082 http://dx.doi.org/10.1186/s12937-017-0300-3 |
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