Cargando…

A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats

The present study was designed to evaluate antiosteoporotic activity of the fresh juice mixtures obtained from Actinidia deliciosa and Garcinia mangostana as well as the pericarp extract of Garcinia mangostana on postmenopausal osteoporosis. 3-month-old female Wistar rats were ovariectiomized and th...

Descripción completa

Detalles Bibliográficos
Autores principales: Vellapandian, Chitra, Sukumaran, Evelyn Sharon, Sivasubramanian, Logeshwaran Ramalingam, Rajabatar Vetrivelan, Venkataramanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745651/
https://www.ncbi.nlm.nih.gov/pubmed/29387722
http://dx.doi.org/10.1155/2017/5349520
_version_ 1783288944550477824
author Vellapandian, Chitra
Sukumaran, Evelyn Sharon
Sivasubramanian, Logeshwaran Ramalingam
Rajabatar Vetrivelan, Venkataramanan
author_facet Vellapandian, Chitra
Sukumaran, Evelyn Sharon
Sivasubramanian, Logeshwaran Ramalingam
Rajabatar Vetrivelan, Venkataramanan
author_sort Vellapandian, Chitra
collection PubMed
description The present study was designed to evaluate antiosteoporotic activity of the fresh juice mixtures obtained from Actinidia deliciosa and Garcinia mangostana as well as the pericarp extract of Garcinia mangostana on postmenopausal osteoporosis. 3-month-old female Wistar rats were ovariectiomized and the treatment began 14 days after ovariectomy and continued for 40 days. Statistically significant changes were noticed in body weight, ash weight, bone mineral content, and femur length and weight followed by serum evaluation and histopathology of femur bone. Administration of the fresh juice mixtures of the fruits of Actinidia deliciosa and Garcinia mangostana prevented ovariectomy-induced bone loss. The administration of the fresh juice mixtures resulted in an increase in the femur length and weight, followed by an increase in the body weight as well as the calcium content obtained from the ash of the femur bone. It is evident that the fresh juice mixtures can be used as a remedy as well as a prophylactic for the prevention of postmenopausal osteoporosis. The present study showed that the combined effect of the fruit juice mixtures of Actinidia deliciosa and Garcinia mangostana was found to be a better treatment for postmenopausal osteoporosis when compared to the pericarp extract of Garcinia mangostana.
format Online
Article
Text
id pubmed-5745651
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-57456512018-01-31 A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats Vellapandian, Chitra Sukumaran, Evelyn Sharon Sivasubramanian, Logeshwaran Ramalingam Rajabatar Vetrivelan, Venkataramanan Biomed Res Int Research Article The present study was designed to evaluate antiosteoporotic activity of the fresh juice mixtures obtained from Actinidia deliciosa and Garcinia mangostana as well as the pericarp extract of Garcinia mangostana on postmenopausal osteoporosis. 3-month-old female Wistar rats were ovariectiomized and the treatment began 14 days after ovariectomy and continued for 40 days. Statistically significant changes were noticed in body weight, ash weight, bone mineral content, and femur length and weight followed by serum evaluation and histopathology of femur bone. Administration of the fresh juice mixtures of the fruits of Actinidia deliciosa and Garcinia mangostana prevented ovariectomy-induced bone loss. The administration of the fresh juice mixtures resulted in an increase in the femur length and weight, followed by an increase in the body weight as well as the calcium content obtained from the ash of the femur bone. It is evident that the fresh juice mixtures can be used as a remedy as well as a prophylactic for the prevention of postmenopausal osteoporosis. The present study showed that the combined effect of the fruit juice mixtures of Actinidia deliciosa and Garcinia mangostana was found to be a better treatment for postmenopausal osteoporosis when compared to the pericarp extract of Garcinia mangostana. Hindawi 2017 2017-12-13 /pmc/articles/PMC5745651/ /pubmed/29387722 http://dx.doi.org/10.1155/2017/5349520 Text en Copyright © 2017 Chitra Vellapandian et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vellapandian, Chitra
Sukumaran, Evelyn Sharon
Sivasubramanian, Logeshwaran Ramalingam
Rajabatar Vetrivelan, Venkataramanan
A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats
title A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats
title_full A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats
title_fullStr A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats
title_full_unstemmed A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats
title_short A Comparative Study of Actinidia deliciosa and Garcinia mangostana in Ovariectomy-Induced Osteoporosis in Female Wistar Rats
title_sort comparative study of actinidia deliciosa and garcinia mangostana in ovariectomy-induced osteoporosis in female wistar rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745651/
https://www.ncbi.nlm.nih.gov/pubmed/29387722
http://dx.doi.org/10.1155/2017/5349520
work_keys_str_mv AT vellapandianchitra acomparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT sukumaranevelynsharon acomparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT sivasubramanianlogeshwaranramalingam acomparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT rajabatarvetrivelanvenkataramanan acomparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT vellapandianchitra comparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT sukumaranevelynsharon comparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT sivasubramanianlogeshwaranramalingam comparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats
AT rajabatarvetrivelanvenkataramanan comparativestudyofactinidiadeliciosaandgarciniamangostanainovariectomyinducedosteoporosisinfemalewistarrats