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Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature

Kikuchi–Fujimoto disease (KFD) is a rare, benign, generally self-limiting disease that has higher prevalence in Asian people with a few cases reported in European countries. It generally affects young subjects under 40 years of age and is characterized by regional lymphadenopathy. Here, we present a...

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Autores principales: D'Introno, A., Perrone, A., Schilardi, A., Gentile, A., Sabbà, C., Napoli, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745701/
https://www.ncbi.nlm.nih.gov/pubmed/29387087
http://dx.doi.org/10.1155/2017/7257902
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author D'Introno, A.
Perrone, A.
Schilardi, A.
Gentile, A.
Sabbà, C.
Napoli, N.
author_facet D'Introno, A.
Perrone, A.
Schilardi, A.
Gentile, A.
Sabbà, C.
Napoli, N.
author_sort D'Introno, A.
collection PubMed
description Kikuchi–Fujimoto disease (KFD) is a rare, benign, generally self-limiting disease that has higher prevalence in Asian people with a few cases reported in European countries. It generally affects young subjects under 40 years of age and is characterized by regional lymphadenopathy. Here, we present a case of a 66-year-old Italian woman who was extensively examined for right unilateral laterocervical lymph nodes associated with fever, night sweats, fatigue, and weight loss. She was diagnosed as having the KFD only after an excision biopsy of the largest laterocervical lymph node and was then managed symptomatically with NSAIDs. We also made a review of the literature for better awareness of the disease among physicians especially in those countries, like Italy, where the disease is not prevalent and may be frequently misdiagnosed. In fact, to our best knowledge, only seven Italian cases of KFD have been published in the last 15 years with patients being younger than 40 years. We finally highlight that it is noteworthy to consider KFD as differential diagnosis of lymphadenopathy even in old patients, and, since a misdiagnosis of lymphoma is actually feasible, an early biopsy has to be taken into account for confirming diagnosis and helping in the timely and appropriate management.
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spelling pubmed-57457012018-01-31 Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature D'Introno, A. Perrone, A. Schilardi, A. Gentile, A. Sabbà, C. Napoli, N. Case Rep Med Case Report Kikuchi–Fujimoto disease (KFD) is a rare, benign, generally self-limiting disease that has higher prevalence in Asian people with a few cases reported in European countries. It generally affects young subjects under 40 years of age and is characterized by regional lymphadenopathy. Here, we present a case of a 66-year-old Italian woman who was extensively examined for right unilateral laterocervical lymph nodes associated with fever, night sweats, fatigue, and weight loss. She was diagnosed as having the KFD only after an excision biopsy of the largest laterocervical lymph node and was then managed symptomatically with NSAIDs. We also made a review of the literature for better awareness of the disease among physicians especially in those countries, like Italy, where the disease is not prevalent and may be frequently misdiagnosed. In fact, to our best knowledge, only seven Italian cases of KFD have been published in the last 15 years with patients being younger than 40 years. We finally highlight that it is noteworthy to consider KFD as differential diagnosis of lymphadenopathy even in old patients, and, since a misdiagnosis of lymphoma is actually feasible, an early biopsy has to be taken into account for confirming diagnosis and helping in the timely and appropriate management. Hindawi 2017 2017-12-14 /pmc/articles/PMC5745701/ /pubmed/29387087 http://dx.doi.org/10.1155/2017/7257902 Text en Copyright © 2017 A. D'Introno et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
D'Introno, A.
Perrone, A.
Schilardi, A.
Gentile, A.
Sabbà, C.
Napoli, N.
Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature
title Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature
title_full Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature
title_fullStr Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature
title_full_unstemmed Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature
title_short Kikuchi–Fujimoto Disease in an Old Italian Woman: Case Report and Review of the Literature
title_sort kikuchi–fujimoto disease in an old italian woman: case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745701/
https://www.ncbi.nlm.nih.gov/pubmed/29387087
http://dx.doi.org/10.1155/2017/7257902
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