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The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans

The present study was designed to explore the possible influence of subacute exposure to lead on the levels of selected essential metals, selected proteins related to them, and oxidative stress parameters in occupationally exposed workers. The study population included 36 males occupationally expose...

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Autores principales: Dobrakowski, Michał, Boroń, Marta, Birkner, Ewa, Kasperczyk, Aleksandra, Chwalińska, Ewa, Lisowska, Grażyna, Kasperczyk, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745737/
https://www.ncbi.nlm.nih.gov/pubmed/29387295
http://dx.doi.org/10.1155/2017/8763793
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author Dobrakowski, Michał
Boroń, Marta
Birkner, Ewa
Kasperczyk, Aleksandra
Chwalińska, Ewa
Lisowska, Grażyna
Kasperczyk, Sławomir
author_facet Dobrakowski, Michał
Boroń, Marta
Birkner, Ewa
Kasperczyk, Aleksandra
Chwalińska, Ewa
Lisowska, Grażyna
Kasperczyk, Sławomir
author_sort Dobrakowski, Michał
collection PubMed
description The present study was designed to explore the possible influence of subacute exposure to lead on the levels of selected essential metals, selected proteins related to them, and oxidative stress parameters in occupationally exposed workers. The study population included 36 males occupationally exposed to lead for 36 to 44 days. Their blood lead level at the beginning of the study was 10.7 ± 7.67 μg/dl and increased to the level of 49.1 ± 14.1 μg/dl at the end of the study. The levels of calcium, magnesium, and zinc increased significantly after lead exposure compared to baseline by 3%, 3%, and 8%, respectively, while the level of copper decreased significantly by 7%. The malondialdehyde (MDA) level and the activities of catalase (CAT) and superoxide dismutase (SOD) did not change due to lead exposure. However, the level of lipid hydroperoxides (LPH) in serum increased significantly by 46%, while the level of erythrocyte lipofuscin (LPS) decreased by 13%. The serum levels of essential metals are modified by a short-term exposure to lead in occupationally exposed workers. A short-term exposure to lead induces oxidative stress associated with elevated levels of LPH but not MDA.
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spelling pubmed-57457372018-01-31 The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans Dobrakowski, Michał Boroń, Marta Birkner, Ewa Kasperczyk, Aleksandra Chwalińska, Ewa Lisowska, Grażyna Kasperczyk, Sławomir Oxid Med Cell Longev Research Article The present study was designed to explore the possible influence of subacute exposure to lead on the levels of selected essential metals, selected proteins related to them, and oxidative stress parameters in occupationally exposed workers. The study population included 36 males occupationally exposed to lead for 36 to 44 days. Their blood lead level at the beginning of the study was 10.7 ± 7.67 μg/dl and increased to the level of 49.1 ± 14.1 μg/dl at the end of the study. The levels of calcium, magnesium, and zinc increased significantly after lead exposure compared to baseline by 3%, 3%, and 8%, respectively, while the level of copper decreased significantly by 7%. The malondialdehyde (MDA) level and the activities of catalase (CAT) and superoxide dismutase (SOD) did not change due to lead exposure. However, the level of lipid hydroperoxides (LPH) in serum increased significantly by 46%, while the level of erythrocyte lipofuscin (LPS) decreased by 13%. The serum levels of essential metals are modified by a short-term exposure to lead in occupationally exposed workers. A short-term exposure to lead induces oxidative stress associated with elevated levels of LPH but not MDA. Hindawi 2017 2017-12-13 /pmc/articles/PMC5745737/ /pubmed/29387295 http://dx.doi.org/10.1155/2017/8763793 Text en Copyright © 2017 Michał Dobrakowski et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dobrakowski, Michał
Boroń, Marta
Birkner, Ewa
Kasperczyk, Aleksandra
Chwalińska, Ewa
Lisowska, Grażyna
Kasperczyk, Sławomir
The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans
title The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans
title_full The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans
title_fullStr The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans
title_full_unstemmed The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans
title_short The Effect of a Short-Term Exposure to Lead on the Levels of Essential Metal Ions, Selected Proteins Related to Them, and Oxidative Stress Parameters in Humans
title_sort effect of a short-term exposure to lead on the levels of essential metal ions, selected proteins related to them, and oxidative stress parameters in humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745737/
https://www.ncbi.nlm.nih.gov/pubmed/29387295
http://dx.doi.org/10.1155/2017/8763793
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