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Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery
Ischemic brain injury triggers an inflammatory response. This response is necessary to clear damaged brain tissue but can also exacerbate brain injury. Microglia are the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745819/ https://www.ncbi.nlm.nih.gov/pubmed/29239311 http://dx.doi.org/10.4103/1673-5374.219026 |
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author | Chen, Hsiao-Huei Stewart, Alexandre F. R. |
author_facet | Chen, Hsiao-Huei Stewart, Alexandre F. R. |
author_sort | Chen, Hsiao-Huei |
collection | PubMed |
description | Ischemic brain injury triggers an inflammatory response. This response is necessary to clear damaged brain tissue but can also exacerbate brain injury. Microglia are the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused synapses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines. This review briefly discusses recent findings pertaining to these regulatory mechanisms in the context of stroke recovery. |
format | Online Article Text |
id | pubmed-5745819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57458192018-01-02 Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery Chen, Hsiao-Huei Stewart, Alexandre F. R. Neural Regen Res Invited Review Ischemic brain injury triggers an inflammatory response. This response is necessary to clear damaged brain tissue but can also exacerbate brain injury. Microglia are the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused synapses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines. This review briefly discusses recent findings pertaining to these regulatory mechanisms in the context of stroke recovery. Medknow Publications & Media Pvt Ltd 2017-11 /pmc/articles/PMC5745819/ /pubmed/29239311 http://dx.doi.org/10.4103/1673-5374.219026 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Chen, Hsiao-Huei Stewart, Alexandre F. R. Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
title | Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
title_full | Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
title_fullStr | Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
title_full_unstemmed | Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
title_short | Interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
title_sort | interferon regulatory factor 2 binding protein 2: a new player of the innate immune response for stroke recovery |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745819/ https://www.ncbi.nlm.nih.gov/pubmed/29239311 http://dx.doi.org/10.4103/1673-5374.219026 |
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