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Expitope 2.0: a tool to assess immunotherapeutic antigens for their potential cross-reactivity against naturally expressed proteins in human tissues

BACKGROUND: Adoptive immunotherapy offers great potential for treating many types of cancer but its clinical application is hampered by cross-reactive T cell responses in healthy human tissues, representing serious safety risks for patients. We previously developed a computational tool called Expito...

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Detalles Bibliográficos
Autores principales:	Jaravine, Victor, Mösch, Anja, Raffegerst, Silke, Schendel, Dolores J., Frishman, Dmitrij
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Software
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745885/ https://www.ncbi.nlm.nih.gov/pubmed/29282079 http://dx.doi.org/10.1186/s12885-017-3854-8

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