Cargando…

Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China

BACKGROUND: The aim of this study was to investigate the optimal vitamin D status in the middle-aged and elderly population residing in Shanghai, China. MATERIAL/METHODS: A total of 1,829 males and postmenopausal females older than 45 years of age in the Changfeng community of Shanghai were included...

Descripción completa

Detalles Bibliográficos
Autores principales: Aleteng, Qiqige, Zhao, Lin, Lin, Huandong, Xia, Mingfeng, Ma, Hui, Gao, Jian, Pan, Baishen, Gao, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745892/
https://www.ncbi.nlm.nih.gov/pubmed/29255137
http://dx.doi.org/10.12659/MSM.904495
_version_ 1783288996263100416
author Aleteng, Qiqige
Zhao, Lin
Lin, Huandong
Xia, Mingfeng
Ma, Hui
Gao, Jian
Pan, Baishen
Gao, Xin
author_facet Aleteng, Qiqige
Zhao, Lin
Lin, Huandong
Xia, Mingfeng
Ma, Hui
Gao, Jian
Pan, Baishen
Gao, Xin
author_sort Aleteng, Qiqige
collection PubMed
description BACKGROUND: The aim of this study was to investigate the optimal vitamin D status in the middle-aged and elderly population residing in Shanghai, China. MATERIAL/METHODS: A total of 1,829 males and postmenopausal females older than 45 years of age in the Changfeng community of Shanghai were included in this study. The optimal vitamin D level was determined according to the suppression of parathyroid hormone (PTH) and the highest bone mineral density (BMD). Locally weighted scatter plot smoothing (LOWESS) was performed to study the correlations of 25(OH)D with PTH and BMD in the lumbar spine and total hip, adjusting for gender, age, weight, use of calcium and vitamin D supplements, eGFR, smoking status, and alcohol consumption. RESULTS: The mean serum 25(OH)D concentration was 48.0±19.2 nmol/L for the whole study population. The circulating PTH was maximally suppressed by the serum 25(OH)D of 55 nmol/L in the total population (60 nmol/L for males and 50 nmol/L for females). The 25(OH)D concentrations corresponding to the highest BMD at lumbar spine (L1–L4) and total hip were 53 nmol/L and 75 nmol/L, respectively, for the whole population. These values were also higher in males than females. CONCLUSIONS: The optimal 25(OH)D concentration of 55 nmol/L is sufficient to maintain the bone health and metabolic status in middle-aged and elderly individuals living in Shanghai. Males probably need higher vitamin D concentration than females. There are differences between vitamin D status based on lumbar spine BMD and total hip BMD.
format Online
Article
Text
id pubmed-5745892
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-57458922018-01-02 Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China Aleteng, Qiqige Zhao, Lin Lin, Huandong Xia, Mingfeng Ma, Hui Gao, Jian Pan, Baishen Gao, Xin Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to investigate the optimal vitamin D status in the middle-aged and elderly population residing in Shanghai, China. MATERIAL/METHODS: A total of 1,829 males and postmenopausal females older than 45 years of age in the Changfeng community of Shanghai were included in this study. The optimal vitamin D level was determined according to the suppression of parathyroid hormone (PTH) and the highest bone mineral density (BMD). Locally weighted scatter plot smoothing (LOWESS) was performed to study the correlations of 25(OH)D with PTH and BMD in the lumbar spine and total hip, adjusting for gender, age, weight, use of calcium and vitamin D supplements, eGFR, smoking status, and alcohol consumption. RESULTS: The mean serum 25(OH)D concentration was 48.0±19.2 nmol/L for the whole study population. The circulating PTH was maximally suppressed by the serum 25(OH)D of 55 nmol/L in the total population (60 nmol/L for males and 50 nmol/L for females). The 25(OH)D concentrations corresponding to the highest BMD at lumbar spine (L1–L4) and total hip were 53 nmol/L and 75 nmol/L, respectively, for the whole population. These values were also higher in males than females. CONCLUSIONS: The optimal 25(OH)D concentration of 55 nmol/L is sufficient to maintain the bone health and metabolic status in middle-aged and elderly individuals living in Shanghai. Males probably need higher vitamin D concentration than females. There are differences between vitamin D status based on lumbar spine BMD and total hip BMD. International Scientific Literature, Inc. 2017-12-19 /pmc/articles/PMC5745892/ /pubmed/29255137 http://dx.doi.org/10.12659/MSM.904495 Text en © Med Sci Monit, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Aleteng, Qiqige
Zhao, Lin
Lin, Huandong
Xia, Mingfeng
Ma, Hui
Gao, Jian
Pan, Baishen
Gao, Xin
Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
title Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
title_full Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
title_fullStr Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
title_full_unstemmed Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
title_short Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
title_sort optimal vitamin d status in a middle-aged and elderly population residing in shanghai, china
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745892/
https://www.ncbi.nlm.nih.gov/pubmed/29255137
http://dx.doi.org/10.12659/MSM.904495
work_keys_str_mv AT aletengqiqige optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT zhaolin optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT linhuandong optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT xiamingfeng optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT mahui optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT gaojian optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT panbaishen optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina
AT gaoxin optimalvitamindstatusinamiddleagedandelderlypopulationresidinginshanghaichina