Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer

Yes-associated protein 1 (YAP1) acts as an oncogene through dephosphorylation and nuclear translocation, and nuclear accumulation of YAP1 is associated with poor prognosis in gastric cancer (GC). We previously identified ivermectin, an antiparasitic drug, as a YAP1 inhibitor. Here, we aimed to clari...

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Detalles Bibliográficos
Autores principales: Nambara, Sho, Masuda, Takaaki, Nishio, Miki, Kuramitsu, Shotaro, Tobo, Taro, Ogawa, Yushi, Hu, Qingjiang, Iguchi, Tomohiro, Kuroda, Yousuke, Ito, Shuhei, Eguchi, Hidetoshi, Sugimachi, Keishi, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko, Suzuki, Akira, Mimori, Koshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746098/
https://www.ncbi.nlm.nih.gov/pubmed/29296196
http://dx.doi.org/10.18632/oncotarget.22587

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