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Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors
Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of metastatic disease in newly-diagnosed sCRC patients...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746100/ https://www.ncbi.nlm.nih.gov/pubmed/29296198 http://dx.doi.org/10.18632/oncotarget.22591 |
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author | Gutiérrez, María Laura Corchete, Luis Antonio Sarasquete, María Eugenia del Mar Abad, María Bengoechea, Oscar Fermiñán, Encarna Anduaga, María Fernanda del Carmen, Sofía Iglesias, Manuel Esteban, Carmen Angoso, María Alcazar, Jose Antonio García, Jacinto Orfao, Alberto Muñoz-Bellvís, Luis Sayagués, José María |
author_facet | Gutiérrez, María Laura Corchete, Luis Antonio Sarasquete, María Eugenia del Mar Abad, María Bengoechea, Oscar Fermiñán, Encarna Anduaga, María Fernanda del Carmen, Sofía Iglesias, Manuel Esteban, Carmen Angoso, María Alcazar, Jose Antonio García, Jacinto Orfao, Alberto Muñoz-Bellvís, Luis Sayagués, José María |
author_sort | Gutiérrez, María Laura |
collection | PubMed |
description | Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of metastatic disease in newly-diagnosed sCRC patients remains a challenge. Here, we evaluated the specific genes and molecular pathways associated with the invasive potential of colorectal tumor cells, through the assessment of the gene expression profile (GEP) of coding and non-coding genes in metastatic (MTX) vs. non-metastatic (non-MTX) primary sCRC tumors followed for >5 years. Overall, MTX tumors showed up-regulation of genes associated with tumor progression and metastatic potential while non-MTX cases displayed GEP associated with higher cell proliferation, activation of DNA repair and anti-tumoral immune/inflammatory responses. Based on only 19 genes a specific GEP that classifies sCRC tumors into two MTX-like and non-MTX-like molecular subgroups was defined which shows an independent prognostic impact on patient overall survival, particularly when it is combined with the lymph node status at diagnosis. In summary, we show an association between the global GEP of primary sCRC cells and their metastatic potential and defined a GEP-based classifier that provides the basis for further prognostic stratification of sCRC patients who are at risk of distant metastases. |
format | Online Article Text |
id | pubmed-5746100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57461002018-01-02 Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors Gutiérrez, María Laura Corchete, Luis Antonio Sarasquete, María Eugenia del Mar Abad, María Bengoechea, Oscar Fermiñán, Encarna Anduaga, María Fernanda del Carmen, Sofía Iglesias, Manuel Esteban, Carmen Angoso, María Alcazar, Jose Antonio García, Jacinto Orfao, Alberto Muñoz-Bellvís, Luis Sayagués, José María Oncotarget Research Paper Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of metastatic disease in newly-diagnosed sCRC patients remains a challenge. Here, we evaluated the specific genes and molecular pathways associated with the invasive potential of colorectal tumor cells, through the assessment of the gene expression profile (GEP) of coding and non-coding genes in metastatic (MTX) vs. non-metastatic (non-MTX) primary sCRC tumors followed for >5 years. Overall, MTX tumors showed up-regulation of genes associated with tumor progression and metastatic potential while non-MTX cases displayed GEP associated with higher cell proliferation, activation of DNA repair and anti-tumoral immune/inflammatory responses. Based on only 19 genes a specific GEP that classifies sCRC tumors into two MTX-like and non-MTX-like molecular subgroups was defined which shows an independent prognostic impact on patient overall survival, particularly when it is combined with the lymph node status at diagnosis. In summary, we show an association between the global GEP of primary sCRC cells and their metastatic potential and defined a GEP-based classifier that provides the basis for further prognostic stratification of sCRC patients who are at risk of distant metastases. Impact Journals LLC 2017-11-21 /pmc/articles/PMC5746100/ /pubmed/29296198 http://dx.doi.org/10.18632/oncotarget.22591 Text en Copyright: © 2017 Gutiérrez et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Gutiérrez, María Laura Corchete, Luis Antonio Sarasquete, María Eugenia del Mar Abad, María Bengoechea, Oscar Fermiñán, Encarna Anduaga, María Fernanda del Carmen, Sofía Iglesias, Manuel Esteban, Carmen Angoso, María Alcazar, Jose Antonio García, Jacinto Orfao, Alberto Muñoz-Bellvís, Luis Sayagués, José María Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
title | Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
title_full | Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
title_fullStr | Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
title_full_unstemmed | Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
title_short | Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
title_sort | prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746100/ https://www.ncbi.nlm.nih.gov/pubmed/29296198 http://dx.doi.org/10.18632/oncotarget.22591 |
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