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Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease

Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 6...

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Autores principales: Su, Sui-Lung, Chen, Wei-Teing, Hsiao, Po-Jen, Lu, Kuo-Cheng, Lin, Yuh-Feng, Lin, Chin, Su, Wen, Yeh, Shih-Jen, Chang, Hung, Lin, Fu-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746107/
https://www.ncbi.nlm.nih.gov/pubmed/29296205
http://dx.doi.org/10.18632/oncotarget.22121
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author Su, Sui-Lung
Chen, Wei-Teing
Hsiao, Po-Jen
Lu, Kuo-Cheng
Lin, Yuh-Feng
Lin, Chin
Su, Wen
Yeh, Shih-Jen
Chang, Hung
Lin, Fu-Huang
author_facet Su, Sui-Lung
Chen, Wei-Teing
Hsiao, Po-Jen
Lu, Kuo-Cheng
Lin, Yuh-Feng
Lin, Chin
Su, Wen
Yeh, Shih-Jen
Chang, Hung
Lin, Fu-Huang
author_sort Su, Sui-Lung
collection PubMed
description Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention.
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spelling pubmed-57461072018-01-02 Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease Su, Sui-Lung Chen, Wei-Teing Hsiao, Po-Jen Lu, Kuo-Cheng Lin, Yuh-Feng Lin, Chin Su, Wen Yeh, Shih-Jen Chang, Hung Lin, Fu-Huang Oncotarget Research Paper Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention. Impact Journals LLC 2017-10-26 /pmc/articles/PMC5746107/ /pubmed/29296205 http://dx.doi.org/10.18632/oncotarget.22121 Text en Copyright: © 2017 Su et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Su, Sui-Lung
Chen, Wei-Teing
Hsiao, Po-Jen
Lu, Kuo-Cheng
Lin, Yuh-Feng
Lin, Chin
Su, Wen
Yeh, Shih-Jen
Chang, Hung
Lin, Fu-Huang
Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
title Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
title_full Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
title_fullStr Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
title_full_unstemmed Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
title_short Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
title_sort angiotensin ii receptor type 1 a1166c modifies the association between angiotensinogen m235t and chronic kidney disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746107/
https://www.ncbi.nlm.nih.gov/pubmed/29296205
http://dx.doi.org/10.18632/oncotarget.22121
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