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Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 6...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746107/ https://www.ncbi.nlm.nih.gov/pubmed/29296205 http://dx.doi.org/10.18632/oncotarget.22121 |
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author | Su, Sui-Lung Chen, Wei-Teing Hsiao, Po-Jen Lu, Kuo-Cheng Lin, Yuh-Feng Lin, Chin Su, Wen Yeh, Shih-Jen Chang, Hung Lin, Fu-Huang |
author_facet | Su, Sui-Lung Chen, Wei-Teing Hsiao, Po-Jen Lu, Kuo-Cheng Lin, Yuh-Feng Lin, Chin Su, Wen Yeh, Shih-Jen Chang, Hung Lin, Fu-Huang |
author_sort | Su, Sui-Lung |
collection | PubMed |
description | Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention. |
format | Online Article Text |
id | pubmed-5746107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57461072018-01-02 Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease Su, Sui-Lung Chen, Wei-Teing Hsiao, Po-Jen Lu, Kuo-Cheng Lin, Yuh-Feng Lin, Chin Su, Wen Yeh, Shih-Jen Chang, Hung Lin, Fu-Huang Oncotarget Research Paper Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention. Impact Journals LLC 2017-10-26 /pmc/articles/PMC5746107/ /pubmed/29296205 http://dx.doi.org/10.18632/oncotarget.22121 Text en Copyright: © 2017 Su et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Su, Sui-Lung Chen, Wei-Teing Hsiao, Po-Jen Lu, Kuo-Cheng Lin, Yuh-Feng Lin, Chin Su, Wen Yeh, Shih-Jen Chang, Hung Lin, Fu-Huang Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease |
title | Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease |
title_full | Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease |
title_fullStr | Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease |
title_full_unstemmed | Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease |
title_short | Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease |
title_sort | angiotensin ii receptor type 1 a1166c modifies the association between angiotensinogen m235t and chronic kidney disease |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746107/ https://www.ncbi.nlm.nih.gov/pubmed/29296205 http://dx.doi.org/10.18632/oncotarget.22121 |
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