Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect

Acetyl coenzyme A (acetyl-CoA) is essential for histone acetylation, to promote cell proliferation by regulating gene expression. However, the underlying mechanism(s) governing acetylation remains poorly understood. Activated α(2)-Macroglobulin (α(2)M(*)) signals through tumor Cell Surface GRP78 (CS...

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Detalles Bibliográficos
Autores principales: Gopal, Udhayakumar, Pizzo, Salvatore V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746117/
https://www.ncbi.nlm.nih.gov/pubmed/29296215
http://dx.doi.org/10.18632/oncotarget.22431

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