Cargando…

Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer

The E3 ubiquitin protein UBR5 has been implicated in the regulation of multiple biological functions and has recently emerged as a key regulator of the ubiquitin-proteasome system (UPS) in cancer. However, the clinical significance and biological function of UBR5 in colorectal cancer (CRC) are poorl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Zhongdong, Liang, Han, Wang, Jinmeng, Xu, Xiaowen, Zhu, Yan, Guo, Aizhen, Shen, Xian, Cao, Fuao, Chang, Wenjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746127/ https://www.ncbi.nlm.nih.gov/pubmed/29296225 http://dx.doi.org/10.18632/oncotarget.22531

Ejemplares similares

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5
por: Shen, Qingya, et al.
Publicado: (2018)

Vacuolar Membrane ATPase Activity 21 Predicts a Favorable Outcome and Acts as a Suppressor in Colorectal Cancer
por: Zhang, Fan, et al.
Publicado: (2021)

Eyes absent homologue 2 predicts a favorable prognosis in colorectal cancer
por: Zheng, Jie, et al.
Publicado: (2018)

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5
por: Hodáková, Zuzana, et al.
Publicado: (2023)

UBR5 oncogene as an indicator of poor prognosis in gastric cancer
por: Ding, Fanghui, et al.
Publicado: (2020)

The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia
por: Shearer, Robert F., et al.
Publicado: (2018)

Specificity in the actions of the UBR1 ubiquitin ligase in the degradation of nuclear receptors()
por: Sultana, Rasheda, et al.
Publicado: (2013)

Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes
por: Kaisari, Sharon, et al.
Publicado: (2022)

Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma
por: Li, Ye, et al.
Publicado: (2021)

A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice
por: Hunt, Liam C., et al.
Publicado: (2019)

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5
por: Panfil, Amanda R., et al.
Publicado: (2018)

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5
por: Flack, Joshua E., et al.
Publicado: (2017)

The effects of the E3 ubiquitin–protein ligase UBR7 of Frankliniella occidentalis on the ability of insects to acquire and transmit TSWV
por: Shi, Junxia, et al.
Publicado: (2023)

Insights into the recognition mechanism in the UBR box of UBR4 for its specific substrates
por: Jeong, Da Eun, et al.
Publicado: (2023)

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis
por: Mellis, David, et al.
Publicado: (2021)

Clinicopathological Features and Prognostic Evaluation of UBR5 in Liver Cancer Patients
por: Huo, Qi, et al.
Publicado: (2022)

Cardiac Na(v)1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6
por: Zhao, Chunxia, et al.
Publicado: (2015)

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans
por: Safdar, Komal, et al.
Publicado: (2016)

Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function
por: Lampersberger, Lisa, et al.
Publicado: (2023)

The Mub1/Ubr2 Ubiquitin Ligase Complex Regulates the Conserved Dsn1 Kinetochore Protein
por: Akiyoshi, Bungo, et al.
Publicado: (2013)

The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans
por: Chitturi, Jyothsna, et al.
Publicado: (2018)

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains
por: Jülg, Julia, et al.
Publicado: (2023)

Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins
por: Nillegoda, Nadinath B., et al.
Publicado: (2010)

Signaling Pathways Regulated by UBR Box-Containing E3 Ligases
por: Kim, Jung Gi, et al.
Publicado: (2021)

Transcription Factor IIS Cooperates with the E3 Ligase UBR5 to Ubiquitinate the CDK9 Subunit of the Positive Transcription Elongation Factor B
por: Cojocaru, Marilena, et al.
Publicado: (2011)

The E3 ubiquitin ligase UBR5 interacts with TTC7A and may be associated with very early onset inflammatory bowel disease
por: Dhingani, Neel, et al.
Publicado: (2020)

E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1
por: Li, Jin, et al.
Publicado: (2021)

Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome
por: Hwang, Cheol-Sang, et al.
Publicado: (2011)

The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation
por: Khosrow-Khavar, Farzin, et al.
Publicado: (2012)

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
por: Koyuncu, Seda, et al.
Publicado: (2018)

CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9
por: Zhang, Yanli, et al.
Publicado: (2021)

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging
por: Hunt, Liam C., et al.
Publicado: (2021)

The Ubiquitin Ligase Ubr2, a Recognition E3 Component of the N-End Rule Pathway, Stabilizes Tex19.1 during Spermatogenesis
por: Yang, Fang, et al.
Publicado: (2010)

Corrigendum: E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1
por: Li, Jin, et al.
Publicado: (2021)

SHP2 associates with nuclear localization of STAT3: significance in progression and prognosis of colorectal cancer
por: Huang, Yan, et al.
Publicado: (2017)

Crystal structure of the UBR‐box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding
por: Muñoz‐Escobar, Juliana, et al.
Publicado: (2017)

UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target
por: Saurabh, Kumar, et al.
Publicado: (2020)

Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin
por: Matsuura, K, et al.
Publicado: (2017)

Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts
por: Xu, Xiaowen, et al.
Publicado: (2019)

Time-of-Day- and Light-Dependent Expression of Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) in the Suprachiasmatic Nucleus Circadian Clock
por: Ling, Harrod H., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_n8l36coreqio46da9qjq5ibfsr