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A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis
Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746208/ https://www.ncbi.nlm.nih.gov/pubmed/29284002 http://dx.doi.org/10.1371/journal.pbio.2002978 |
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author | Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin |
author_facet | Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin |
author_sort | Gao, Yi-Qun |
collection | PubMed |
description | Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general. |
format | Online Article Text |
id | pubmed-5746208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57462082018-01-08 A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin PLoS Biol Research Article Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general. Public Library of Science 2017-12-28 /pmc/articles/PMC5746208/ /pubmed/29284002 http://dx.doi.org/10.1371/journal.pbio.2002978 Text en © 2017 Gao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gao, Yi-Qun Chen, Jiu-Geng Chen, Zi-Ru An, Dong Lv, Qiao-Yan Han, Mei-Ling Wang, Ya-Ling Salt, David E. Chao, Dai-Yin A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
title | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
title_full | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
title_fullStr | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
title_full_unstemmed | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
title_short | A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis |
title_sort | new vesicle trafficking regulator ctl1 plays a crucial role in ion homeostasis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746208/ https://www.ncbi.nlm.nih.gov/pubmed/29284002 http://dx.doi.org/10.1371/journal.pbio.2002978 |
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