Cargando…

Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma

Tongue squamous cell carcinoma (TSCC) is more aggressive than other cancers in the head and neck region because of its potential for metastasis. Recently, β2-adrenergic receptor (β2-AR) has been reported to be a potential promoter in various types of solid cancer. However, the role of β2-AR and its...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Haichao, Wang, Cheng, Xie, Nan, Zhuang, Zehang, Liu, Xiqiang, Hou, Jinsong, Huang, Hongzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746304/
https://www.ncbi.nlm.nih.gov/pubmed/29138797
http://dx.doi.org/10.3892/ijmm.2017.3248
_version_ 1783289080264523776
author Liu, Haichao
Wang, Cheng
Xie, Nan
Zhuang, Zehang
Liu, Xiqiang
Hou, Jinsong
Huang, Hongzhang
author_facet Liu, Haichao
Wang, Cheng
Xie, Nan
Zhuang, Zehang
Liu, Xiqiang
Hou, Jinsong
Huang, Hongzhang
author_sort Liu, Haichao
collection PubMed
description Tongue squamous cell carcinoma (TSCC) is more aggressive than other cancers in the head and neck region because of its potential for metastasis. Recently, β2-adrenergic receptor (β2-AR) has been reported to be a potential promoter in various types of solid cancer. However, the role of β2-AR and its effect on TSCC is not well documented. Histological staining, western blot analysis, migration and invasion assay were used. In this study, the expression of β2-AR was increased in TSCC tissue compared with adjacent non-cancerous epithelium. Further analysis demonstrated that increased expression of β2-AR was correlated with differentiation, lymph node metastasis and reduced overall survival rate in patients with TSCC. In vitro studies confirmed that activation of β2-AR can promote epithelial mesenchymal transition in TSCC by initiating an interleukin-6/Stat3/Snail1 pathway. These results suggest that β2-AR has an oncogenic role in TSCC and may be a potential therapeutic target in TSCC.
format Online
Article
Text
id pubmed-5746304
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-57463042017-12-31 Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma Liu, Haichao Wang, Cheng Xie, Nan Zhuang, Zehang Liu, Xiqiang Hou, Jinsong Huang, Hongzhang Int J Mol Med Articles Tongue squamous cell carcinoma (TSCC) is more aggressive than other cancers in the head and neck region because of its potential for metastasis. Recently, β2-adrenergic receptor (β2-AR) has been reported to be a potential promoter in various types of solid cancer. However, the role of β2-AR and its effect on TSCC is not well documented. Histological staining, western blot analysis, migration and invasion assay were used. In this study, the expression of β2-AR was increased in TSCC tissue compared with adjacent non-cancerous epithelium. Further analysis demonstrated that increased expression of β2-AR was correlated with differentiation, lymph node metastasis and reduced overall survival rate in patients with TSCC. In vitro studies confirmed that activation of β2-AR can promote epithelial mesenchymal transition in TSCC by initiating an interleukin-6/Stat3/Snail1 pathway. These results suggest that β2-AR has an oncogenic role in TSCC and may be a potential therapeutic target in TSCC. D.A. Spandidos 2018-01 2017-11-09 /pmc/articles/PMC5746304/ /pubmed/29138797 http://dx.doi.org/10.3892/ijmm.2017.3248 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Haichao
Wang, Cheng
Xie, Nan
Zhuang, Zehang
Liu, Xiqiang
Hou, Jinsong
Huang, Hongzhang
Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
title Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
title_full Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
title_fullStr Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
title_full_unstemmed Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
title_short Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
title_sort activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746304/
https://www.ncbi.nlm.nih.gov/pubmed/29138797
http://dx.doi.org/10.3892/ijmm.2017.3248
work_keys_str_mv AT liuhaichao activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma
AT wangcheng activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma
AT xienan activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma
AT zhuangzehang activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma
AT liuxiqiang activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma
AT houjinsong activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma
AT huanghongzhang activationofadrenergicreceptorb2promotestumorprogressionandepithelialmesenchymaltransitionintonguesquamouscellcarcinoma