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Domain retention in transcription factor fusion genes and its biological and clinical implications: a pan-cancer study
Genomic rearrangements involving transcription factors (TFs) can form fusion proteins resulting in either enhanced, weakened, or even loss of TF activity. Functional domain (FD) retention is a critical factor in the activity of transcription factor fusion genes (TFFGs). A systematic investigation of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746368/ https://www.ncbi.nlm.nih.gov/pubmed/29299133 http://dx.doi.org/10.18632/oncotarget.22653 |