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Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis

Acquired resistance (AQR) to drug treatment occurs frequently in cancer patients and remains an impediment to successful therapy. The aim of this study was to gain insight into how AQR arises following the application of PI3K/mTOR inhibitors. H1975 lung cancer cells with EGFR T790M mutations that co...

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Detalles Bibliográficos
Autores principales:	Koh, King Xin, Tan, Gim Hwa, Hui Low, Sarah Hong, Mohd Omar, Mohd Feroz, Han, Min Ji, Iacopetta, Barry, Soo, Ross, Beloueche-Babari, Mounia, Bhattacharya, Bhaskar, Soong, Richie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746370/ https://www.ncbi.nlm.nih.gov/pubmed/29299135 http://dx.doi.org/10.18632/oncotarget.22655

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