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Identify clear cell renal cell carcinoma related genes by gene network
Clear cell renal cell carcinoma (ccRCC) is the most prominent type of kidney cancer in adults. The patients within metastatic ccRCC have a poor 5-year survival rate that is less than 10%. It is essential to identify ccRCC -related genes to help with the understanding of molecular mechanism of ccRCC....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746388/ https://www.ncbi.nlm.nih.gov/pubmed/29299153 http://dx.doi.org/10.18632/oncotarget.22769 |
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author | Yan, Fangrong Wang, Yue Liu, Chunhui Zhao, Huiling Zhang, Liya Lu, Xiaofan Chen, Chen Wang, Yaoyan Lu, Tao Wang, Fei |
author_facet | Yan, Fangrong Wang, Yue Liu, Chunhui Zhao, Huiling Zhang, Liya Lu, Xiaofan Chen, Chen Wang, Yaoyan Lu, Tao Wang, Fei |
author_sort | Yan, Fangrong |
collection | PubMed |
description | Clear cell renal cell carcinoma (ccRCC) is the most prominent type of kidney cancer in adults. The patients within metastatic ccRCC have a poor 5-year survival rate that is less than 10%. It is essential to identify ccRCC -related genes to help with the understanding of molecular mechanism of ccRCC. In this literature, we aim to identify genes related to ccRCC based on a gene network. We collected gene expression level data of ccRCC from the Cancer Genome Atlas (TCGA) for our analysis. We constructed a co-expression gene network as the first step of our study. Then, the network sparse boosting approach was performed to select the genes which are relevant to ccRCC. Results of our study show there are 15 genes selected from the all genes we collected. Among these genes, 7 of them have been demonstrated to play a key role in development and progression or in drug response of ccRCC. This finding offers clues of gene markers for the treatment of ccRCC. |
format | Online Article Text |
id | pubmed-5746388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57463882018-01-03 Identify clear cell renal cell carcinoma related genes by gene network Yan, Fangrong Wang, Yue Liu, Chunhui Zhao, Huiling Zhang, Liya Lu, Xiaofan Chen, Chen Wang, Yaoyan Lu, Tao Wang, Fei Oncotarget Research Paper Clear cell renal cell carcinoma (ccRCC) is the most prominent type of kidney cancer in adults. The patients within metastatic ccRCC have a poor 5-year survival rate that is less than 10%. It is essential to identify ccRCC -related genes to help with the understanding of molecular mechanism of ccRCC. In this literature, we aim to identify genes related to ccRCC based on a gene network. We collected gene expression level data of ccRCC from the Cancer Genome Atlas (TCGA) for our analysis. We constructed a co-expression gene network as the first step of our study. Then, the network sparse boosting approach was performed to select the genes which are relevant to ccRCC. Results of our study show there are 15 genes selected from the all genes we collected. Among these genes, 7 of them have been demonstrated to play a key role in development and progression or in drug response of ccRCC. This finding offers clues of gene markers for the treatment of ccRCC. Impact Journals LLC 2017-11-30 /pmc/articles/PMC5746388/ /pubmed/29299153 http://dx.doi.org/10.18632/oncotarget.22769 Text en Copyright: © 2017 Yan et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Yan, Fangrong Wang, Yue Liu, Chunhui Zhao, Huiling Zhang, Liya Lu, Xiaofan Chen, Chen Wang, Yaoyan Lu, Tao Wang, Fei Identify clear cell renal cell carcinoma related genes by gene network |
title | Identify clear cell renal cell carcinoma related genes by gene network |
title_full | Identify clear cell renal cell carcinoma related genes by gene network |
title_fullStr | Identify clear cell renal cell carcinoma related genes by gene network |
title_full_unstemmed | Identify clear cell renal cell carcinoma related genes by gene network |
title_short | Identify clear cell renal cell carcinoma related genes by gene network |
title_sort | identify clear cell renal cell carcinoma related genes by gene network |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746388/ https://www.ncbi.nlm.nih.gov/pubmed/29299153 http://dx.doi.org/10.18632/oncotarget.22769 |
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