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XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose

XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear export by inhibiting XPO1. The first SINE compoun...

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Detalles Bibliográficos
Autores principales:	Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746399/ https://www.ncbi.nlm.nih.gov/pubmed/29299164 http://dx.doi.org/10.18632/oncotarget.22801

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