LncRNAs and their role in cancer stem cells

Cancer stem cells (CSCs) play a vital role in the formation of tumors and have been studied as a target of anticancer therapy. Long non-coding RNAs (lncRNAs) are important in the genesis and progression of cancer. Various lncRNAs, such as ROR, HOTAIR, H19, UCA1, and ARSR, are involved in cancer stem...

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Autores principales: Chen, Shusen, Zhu, Jiamin, Wang, Feng, Guan, Zhifeng, Ge, Yangyang, Yang, Xi, Cai, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746414/
https://www.ncbi.nlm.nih.gov/pubmed/29299179
http://dx.doi.org/10.18632/oncotarget.22161
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author Chen, Shusen
Zhu, Jiamin
Wang, Feng
Guan, Zhifeng
Ge, Yangyang
Yang, Xi
Cai, Jing
author_facet Chen, Shusen
Zhu, Jiamin
Wang, Feng
Guan, Zhifeng
Ge, Yangyang
Yang, Xi
Cai, Jing
author_sort Chen, Shusen
collection PubMed
description Cancer stem cells (CSCs) play a vital role in the formation of tumors and have been studied as a target of anticancer therapy. Long non-coding RNAs (lncRNAs) are important in the genesis and progression of cancer. Various lncRNAs, such as ROR, HOTAIR, H19, UCA1, and ARSR, are involved in cancer stemness. These lncRNAs could regulate the expression of CSC-related transcriptional factors, such as SOX2, OCT4, and NANOG, in colorectal, prostate, bladder, breast, liver, and other cancer types. In this work, we review the progress of lncRNAs and cancer stem cells and discuss the potential signal pathways of lncRNAs in cancer stemness.
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spelling pubmed-57464142018-01-03 LncRNAs and their role in cancer stem cells Chen, Shusen Zhu, Jiamin Wang, Feng Guan, Zhifeng Ge, Yangyang Yang, Xi Cai, Jing Oncotarget Review Cancer stem cells (CSCs) play a vital role in the formation of tumors and have been studied as a target of anticancer therapy. Long non-coding RNAs (lncRNAs) are important in the genesis and progression of cancer. Various lncRNAs, such as ROR, HOTAIR, H19, UCA1, and ARSR, are involved in cancer stemness. These lncRNAs could regulate the expression of CSC-related transcriptional factors, such as SOX2, OCT4, and NANOG, in colorectal, prostate, bladder, breast, liver, and other cancer types. In this work, we review the progress of lncRNAs and cancer stem cells and discuss the potential signal pathways of lncRNAs in cancer stemness. Impact Journals LLC 2017-10-30 /pmc/articles/PMC5746414/ /pubmed/29299179 http://dx.doi.org/10.18632/oncotarget.22161 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Chen, Shusen
Zhu, Jiamin
Wang, Feng
Guan, Zhifeng
Ge, Yangyang
Yang, Xi
Cai, Jing
LncRNAs and their role in cancer stem cells
title LncRNAs and their role in cancer stem cells
title_full LncRNAs and their role in cancer stem cells
title_fullStr LncRNAs and their role in cancer stem cells
title_full_unstemmed LncRNAs and their role in cancer stem cells
title_short LncRNAs and their role in cancer stem cells
title_sort lncrnas and their role in cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746414/
https://www.ncbi.nlm.nih.gov/pubmed/29299179
http://dx.doi.org/10.18632/oncotarget.22161
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