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Cilostazol attenuates kainic acid-induced hippocampal cell death

Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent....

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Autores principales: Park, Young-Seop, Jin, Zhen, Jeong, Eun Ae, Yi, Chin-ok, Lee, Jong Youl, Park, In Sung, Roh, Gu Seob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746513/
https://www.ncbi.nlm.nih.gov/pubmed/29302213
http://dx.doi.org/10.4196/kjpp.2018.22.1.63
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author Park, Young-Seop
Jin, Zhen
Jeong, Eun Ae
Yi, Chin-ok
Lee, Jong Youl
Park, In Sung
Roh, Gu Seob
author_facet Park, Young-Seop
Jin, Zhen
Jeong, Eun Ae
Yi, Chin-ok
Lee, Jong Youl
Park, In Sung
Roh, Gu Seob
author_sort Park, Young-Seop
collection PubMed
description Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.
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spelling pubmed-57465132018-01-05 Cilostazol attenuates kainic acid-induced hippocampal cell death Park, Young-Seop Jin, Zhen Jeong, Eun Ae Yi, Chin-ok Lee, Jong Youl Park, In Sung Roh, Gu Seob Korean J Physiol Pharmacol Original Article Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity. The Korean Physiological Society and The Korean Society of Pharmacology 2018-01 2017-12-22 /pmc/articles/PMC5746513/ /pubmed/29302213 http://dx.doi.org/10.4196/kjpp.2018.22.1.63 Text en Copyright © Korean J Physiol Pharmacol http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Young-Seop
Jin, Zhen
Jeong, Eun Ae
Yi, Chin-ok
Lee, Jong Youl
Park, In Sung
Roh, Gu Seob
Cilostazol attenuates kainic acid-induced hippocampal cell death
title Cilostazol attenuates kainic acid-induced hippocampal cell death
title_full Cilostazol attenuates kainic acid-induced hippocampal cell death
title_fullStr Cilostazol attenuates kainic acid-induced hippocampal cell death
title_full_unstemmed Cilostazol attenuates kainic acid-induced hippocampal cell death
title_short Cilostazol attenuates kainic acid-induced hippocampal cell death
title_sort cilostazol attenuates kainic acid-induced hippocampal cell death
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746513/
https://www.ncbi.nlm.nih.gov/pubmed/29302213
http://dx.doi.org/10.4196/kjpp.2018.22.1.63
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