Cargando…
Cilostazol attenuates kainic acid-induced hippocampal cell death
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent....
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746513/ https://www.ncbi.nlm.nih.gov/pubmed/29302213 http://dx.doi.org/10.4196/kjpp.2018.22.1.63 |
_version_ | 1783289114990215168 |
---|---|
author | Park, Young-Seop Jin, Zhen Jeong, Eun Ae Yi, Chin-ok Lee, Jong Youl Park, In Sung Roh, Gu Seob |
author_facet | Park, Young-Seop Jin, Zhen Jeong, Eun Ae Yi, Chin-ok Lee, Jong Youl Park, In Sung Roh, Gu Seob |
author_sort | Park, Young-Seop |
collection | PubMed |
description | Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity. |
format | Online Article Text |
id | pubmed-5746513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Physiological Society and The Korean Society of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57465132018-01-05 Cilostazol attenuates kainic acid-induced hippocampal cell death Park, Young-Seop Jin, Zhen Jeong, Eun Ae Yi, Chin-ok Lee, Jong Youl Park, In Sung Roh, Gu Seob Korean J Physiol Pharmacol Original Article Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity. The Korean Physiological Society and The Korean Society of Pharmacology 2018-01 2017-12-22 /pmc/articles/PMC5746513/ /pubmed/29302213 http://dx.doi.org/10.4196/kjpp.2018.22.1.63 Text en Copyright © Korean J Physiol Pharmacol http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Young-Seop Jin, Zhen Jeong, Eun Ae Yi, Chin-ok Lee, Jong Youl Park, In Sung Roh, Gu Seob Cilostazol attenuates kainic acid-induced hippocampal cell death |
title | Cilostazol attenuates kainic acid-induced hippocampal cell death |
title_full | Cilostazol attenuates kainic acid-induced hippocampal cell death |
title_fullStr | Cilostazol attenuates kainic acid-induced hippocampal cell death |
title_full_unstemmed | Cilostazol attenuates kainic acid-induced hippocampal cell death |
title_short | Cilostazol attenuates kainic acid-induced hippocampal cell death |
title_sort | cilostazol attenuates kainic acid-induced hippocampal cell death |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746513/ https://www.ncbi.nlm.nih.gov/pubmed/29302213 http://dx.doi.org/10.4196/kjpp.2018.22.1.63 |
work_keys_str_mv | AT parkyoungseop cilostazolattenuateskainicacidinducedhippocampalcelldeath AT jinzhen cilostazolattenuateskainicacidinducedhippocampalcelldeath AT jeongeunae cilostazolattenuateskainicacidinducedhippocampalcelldeath AT yichinok cilostazolattenuateskainicacidinducedhippocampalcelldeath AT leejongyoul cilostazolattenuateskainicacidinducedhippocampalcelldeath AT parkinsung cilostazolattenuateskainicacidinducedhippocampalcelldeath AT rohguseob cilostazolattenuateskainicacidinducedhippocampalcelldeath |