Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

KEY POINTS: Omecamtiv mecarbil and blebbistatin perturb the regulatory state of the thick filament in heart muscle. Omecamtiv mecarbil increases contractility at low levels of activation by stabilizing the ON state of the thick filament. Omecamtiv mecarbil decreases contractility at high levels of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Kampourakis, Thomas, Zhang, Xuemeng, Sun, Yin‐Biao, Irving, Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cardiovascular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746517/
https://www.ncbi.nlm.nih.gov/pubmed/29052230
http://dx.doi.org/10.1113/JP275050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746517/
https://www.ncbi.nlm.nih.gov/pubmed/29052230
http://dx.doi.org/10.1113/JP275050

Ejemplares similares