Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning

Sonic Hedgehog (Shh) is a ventrally enriched morphogen controlling dorsoventral patterning of the neural tube. In the dorsal spinal cord, Gli3 protein bound to suppressor-of-fused (Sufu) is converted into Gli3 repressor (Gli3R), which inhibits Shh-target genes. Activation of Shh signalling prevents...

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Detalles Bibliográficos
Autores principales: Kawano, Rie, Ohta, Kunimasa, Lupo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746549/
https://www.ncbi.nlm.nih.gov/pubmed/29263249
http://dx.doi.org/10.1098/rsob.170225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746549/
https://www.ncbi.nlm.nih.gov/pubmed/29263249
http://dx.doi.org/10.1098/rsob.170225

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