Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation

The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans). Plk4-mediated phosphorylation of Ana2/STIL in its conserved STAN motif has been shown to promote its interaction wi...

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Detalles Bibliográficos
Autores principales: Dzhindzhev, Nikola S., Tzolovsky, George, Lipinszki, Zoltan, Abdelaziz, Mohammed, Debski, Janus, Dadlez, Michal, Glover, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746551/
https://www.ncbi.nlm.nih.gov/pubmed/29263250
http://dx.doi.org/10.1098/rsob.170247

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