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Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States

Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in a concerted manner remains unclear. Using pharmacogenetic,...

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Autores principales: Viskaitis, Paulius, Irvine, Elaine E., Smith, Mark A., Choudhury, Agharul I., Alvarez-Curto, Elisa, Glegola, Justyna A., Hardy, Darran G., Pedroni, Silvia M.A., Paiva Pessoa, Maria R., Fernando, Anushka B.P., Katsouri, Loukia, Sardini, Alessandro, Ungless, Mark A., Milligan, Graeme, Withers, Dominic J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746599/
https://www.ncbi.nlm.nih.gov/pubmed/29262334
http://dx.doi.org/10.1016/j.celrep.2017.11.089
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author Viskaitis, Paulius
Irvine, Elaine E.
Smith, Mark A.
Choudhury, Agharul I.
Alvarez-Curto, Elisa
Glegola, Justyna A.
Hardy, Darran G.
Pedroni, Silvia M.A.
Paiva Pessoa, Maria R.
Fernando, Anushka B.P.
Katsouri, Loukia
Sardini, Alessandro
Ungless, Mark A.
Milligan, Graeme
Withers, Dominic J.
author_facet Viskaitis, Paulius
Irvine, Elaine E.
Smith, Mark A.
Choudhury, Agharul I.
Alvarez-Curto, Elisa
Glegola, Justyna A.
Hardy, Darran G.
Pedroni, Silvia M.A.
Paiva Pessoa, Maria R.
Fernando, Anushka B.P.
Katsouri, Loukia
Sardini, Alessandro
Ungless, Mark A.
Milligan, Graeme
Withers, Dominic J.
author_sort Viskaitis, Paulius
collection PubMed
description Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in a concerted manner remains unclear. Using pharmacogenetic, optogenetic, and calcium imaging approaches with a battery of behavioral assays, we demonstrate that VMH steroidogenic factor 1 (SF1) neurons constitute a nutritionally sensitive switch, modulating the competing motivations of feeding and avoidance of potentially dangerous environments. Acute alteration of SF1 neuronal activity alters food intake via changes in appetite and feeding-related behaviors, including locomotion, exploration, anxiety, and valence. In turn, intrinsic SF1 neuron activity is low during feeding and increases with both feeding termination and stress. Our findings identify SF1 neurons as a key part of the neurocircuitry that controls both feeding and related affective states, giving potential insights into the relationship between disordered eating and stress-associated psychological disorders in humans.
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spelling pubmed-57465992018-01-02 Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States Viskaitis, Paulius Irvine, Elaine E. Smith, Mark A. Choudhury, Agharul I. Alvarez-Curto, Elisa Glegola, Justyna A. Hardy, Darran G. Pedroni, Silvia M.A. Paiva Pessoa, Maria R. Fernando, Anushka B.P. Katsouri, Loukia Sardini, Alessandro Ungless, Mark A. Milligan, Graeme Withers, Dominic J. Cell Rep Article Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in a concerted manner remains unclear. Using pharmacogenetic, optogenetic, and calcium imaging approaches with a battery of behavioral assays, we demonstrate that VMH steroidogenic factor 1 (SF1) neurons constitute a nutritionally sensitive switch, modulating the competing motivations of feeding and avoidance of potentially dangerous environments. Acute alteration of SF1 neuronal activity alters food intake via changes in appetite and feeding-related behaviors, including locomotion, exploration, anxiety, and valence. In turn, intrinsic SF1 neuron activity is low during feeding and increases with both feeding termination and stress. Our findings identify SF1 neurons as a key part of the neurocircuitry that controls both feeding and related affective states, giving potential insights into the relationship between disordered eating and stress-associated psychological disorders in humans. Cell Press 2017-12-19 /pmc/articles/PMC5746599/ /pubmed/29262334 http://dx.doi.org/10.1016/j.celrep.2017.11.089 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Viskaitis, Paulius
Irvine, Elaine E.
Smith, Mark A.
Choudhury, Agharul I.
Alvarez-Curto, Elisa
Glegola, Justyna A.
Hardy, Darran G.
Pedroni, Silvia M.A.
Paiva Pessoa, Maria R.
Fernando, Anushka B.P.
Katsouri, Loukia
Sardini, Alessandro
Ungless, Mark A.
Milligan, Graeme
Withers, Dominic J.
Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
title Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
title_full Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
title_fullStr Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
title_full_unstemmed Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
title_short Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
title_sort modulation of sf1 neuron activity coordinately regulates both feeding behavior and associated emotional states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746599/
https://www.ncbi.nlm.nih.gov/pubmed/29262334
http://dx.doi.org/10.1016/j.celrep.2017.11.089
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