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Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC. Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediated apoptosis as an alternative cell death program in caspase...

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Detalles Bibliográficos
Autores principales:	Van Opdenbosch, Nina, Van Gorp, Hanne, Verdonckt, Maarten, Saavedra, Pedro H.V., de Vasconcelos, Nathalia M., Gonçalves, Amanda, Vande Walle, Lieselotte, Demon, Dieter, Matusiak, Magdalena, Van Hauwermeiren, Filip, D’Hont, Jinke, Hochepied, Tino, Krautwald, Stefan, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746600/ https://www.ncbi.nlm.nih.gov/pubmed/29262324 http://dx.doi.org/10.1016/j.celrep.2017.11.088

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