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Moving Toward Standardization of Urine Albumin Measurements

Measurement of urine albumin is important for detecting and monitoring kidney disease. At the present time, measurement of urine albumin is not standardized due to the lack of a reference system, which includes both a reference measurement procedure and certified reference materials. Developing a re...

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Detalles Bibliográficos
Autores principales: Seegmiller, Jesse C., Miller, W. Greg, Bachmann, Lorin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746835/
https://www.ncbi.nlm.nih.gov/pubmed/29333145
Descripción
Sumario:Measurement of urine albumin is important for detecting and monitoring kidney disease. At the present time, measurement of urine albumin is not standardized due to the lack of a reference system, which includes both a reference measurement procedure and certified reference materials. Developing a reference system will provide a means for clinical laboratory measurement procedures to become standardized and will enable successful use of uniform clinical decision points. Currently, urine albumin results vary in excess of 40% depending on which commercially available measurement procedure is utilized for measurement. Clinicians may struggle with classification of kidney disease in part due to differences in measurements from lack of agreement among laboratory methodologies employed when assessing urine albumin concentrations. This report focuses on current findings in urine albumin testing, highlights important measurement and reporting considerations, and presents strategies for developing a reference measurement procedure to enable standardization of urine albumin measurements.