Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist

[Image: see text] Salvinorin A (SalA) is a plant metabolite that agonizes the human kappa-opioid receptor (κ-OR) with high affinity and high selectivity over mu- and delta-opioid receptors. Its therapeutic potential has stimulated extensive semisynthetic studies and total synthesis campaigns. Howeve...

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Detalles Bibliográficos
Autores principales: Roach, Jeremy J., Sasano, Yusuke, Schmid, Cullen L., Zaidi, Saheem, Katritch, Vsevolod, Stevens, Raymond C., Bohn, Laura M., Shenvi, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746855/
https://www.ncbi.nlm.nih.gov/pubmed/29296674
http://dx.doi.org/10.1021/acscentsci.7b00488

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