Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

[Image: see text] The diterpenoid ester ingenol mebutate (IngMeb) is the active ingredient in the topical drug Picato, a first-in-class treatment for the precancerous skin condition actinic keratosis. IngMeb is proposed to exert its therapeutic effects through a dual mode of action involving (i) ind...

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Detalles Bibliográficos
Autores principales: Parker, Christopher G., Kuttruff, Christian A., Galmozzi, Andrea, Jørgensen, Lars, Yeh, Chien-Hung, Hermanson, Daniel J., Wang, Yujia, Artola, Marta, McKerrall, Steven J., Josyln, Christopher M., Nørremark, Bjarne, Dünstl, Georg, Felding, Jakob, Saez, Enrique, Baran, Phil S., Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746860/
https://www.ncbi.nlm.nih.gov/pubmed/29296668
http://dx.doi.org/10.1021/acscentsci.7b00420

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