Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases

[Image: see text] Dysregulation of protein tyrosine phosphorylation has been implicated in a number of human diseases, including cancer, diabetes, and neurodegenerative diseases. As a result of their essential role in regulating protein tyrosine phosphorylation levels, protein tyrosine phosphatases...

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Detalles Bibliográficos
Autores principales: Tjin, Caroline Chandra, Otley, Kate D., Baguley, Tyler D., Kurup, Pradeep, Xu, Jian, Nairn, Angus C., Lombroso, Paul J., Ellman, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746864/
https://www.ncbi.nlm.nih.gov/pubmed/29296673
http://dx.doi.org/10.1021/acscentsci.7b00486

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