Clinical significance of bilateral leg edema and added value of monitoring weight gain during follow‐up of patients with established heart failure

PURPOSE: This study evaluated the clinical characteristics of bilateral leg edema during follow‐up of heart failure (HF) patients and determined the added value of monitoring fluid weight gain for deciding whether this non‐specific sign is a more clinically relevant sign. METHODS: Retrospective analysis was performed on 1826 visits from 83 ambulatory patients with established mild‐to‐moderate HF. Evaluated HF‐related signs included leg edema, pulmonary crackles, S3, weight gain, and ultrasound pleural effusion. RESULTS: During follow‐up, 75 patients with 161 visits had at least one of the following HF‐related events: weight gain (n = 107), leg edema (n = 90), ultrasound pleural effusion (n = 85), pulmonary crackles (n = 29), and S3 (n = 16). Compared with the events of sole leg edema (n = 23), leg edema events with additional HF‐related sign(s) (n = 67) accompanied more symptomatic worsening (7% vs. 55%, P < 0.0001), and a higher incidence (61% vs. 96%, P = 0.0002) and magnitude of increased serum B‐type natriuretic peptide. Sole leg edema events rarely progressed to worsening HF before the next regular clinic visit. Patients with the event of both leg edema and weight gain more often experienced worsening HF requiring extra clinic visits and/or hospitalization. Amongst a total of 67 leg edema events with additional HF‐related signs, 56 (84%) coexisted with weight gain. Therefore, additional monitoring of weight gain efficiently distinguished the clinically significant leg edema events from insignificant sole leg edema events. CONCLUSIONS: During follow‐up of mild‐to‐moderate HF patients, sole leg edema appeared around 30% of the leg edema events, which is considered clinically insignificant. Additional checking for weight gain could be useful for determining whether this sign is a clinically relevant HF‐related sign. The appearance of these both signs during follow‐up of established HF patients should be intentionally watched or treated by extra diuretics and/or drug adjustment to prevent worsening of HF.