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The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy

BACKGROUND: Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typic...

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Autores principales: Noble, Jonathan J., Chruscikowski, Emily, Fry, Nicola R. D., Lewis, Andrew P., Gough, Martin, Shortland, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747099/
https://www.ncbi.nlm.nih.gov/pubmed/29284423
http://dx.doi.org/10.1186/s12883-017-1005-0
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author Noble, Jonathan J.
Chruscikowski, Emily
Fry, Nicola R. D.
Lewis, Andrew P.
Gough, Martin
Shortland, Adam P.
author_facet Noble, Jonathan J.
Chruscikowski, Emily
Fry, Nicola R. D.
Lewis, Andrew P.
Gough, Martin
Shortland, Adam P.
author_sort Noble, Jonathan J.
collection PubMed
description BACKGROUND: Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typically developing peers. METHODS: Twenty-five participants with bilateral cerebral palsy (aged 14.7±3.0 years, GMFCS level I-III) and 25 of their typically developing peers (aged 16.8±3.3 years) took part in this study. None of the participants had undergone orthopaedic surgery, botulinum toxin injections, or serial casting in the previous year. All participants underwent magnetic resonance imaging of both lower limbs. Nine major muscles of each lower limb were individually manually segmented and the muscle volumes calculated. RESULTS: Body mass and total lower limb muscle volume were significantly linearly related in both the cerebral palsy (R(2) = 0.75, p<0.001) and typically developing (R(2) = 0.77, p<0.001) groups. The slope of the relationship between muscle volume and body mass was significantly shallower in the cerebral palsy group compared to the typically developing group (p=0.007). CONCLUSIONS: This cross-sectional study suggests that the increase in size of lower limb muscles relative to body mass is reduced in adolescents and young adults with cerebral palsy. Longitudinal studies are required to further investigate altered muscle growth trajectories in this group and their impact on long-term mobility. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-017-1005-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-57470992018-01-03 The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy Noble, Jonathan J. Chruscikowski, Emily Fry, Nicola R. D. Lewis, Andrew P. Gough, Martin Shortland, Adam P. BMC Neurol Research Article BACKGROUND: Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typically developing peers. METHODS: Twenty-five participants with bilateral cerebral palsy (aged 14.7±3.0 years, GMFCS level I-III) and 25 of their typically developing peers (aged 16.8±3.3 years) took part in this study. None of the participants had undergone orthopaedic surgery, botulinum toxin injections, or serial casting in the previous year. All participants underwent magnetic resonance imaging of both lower limbs. Nine major muscles of each lower limb were individually manually segmented and the muscle volumes calculated. RESULTS: Body mass and total lower limb muscle volume were significantly linearly related in both the cerebral palsy (R(2) = 0.75, p<0.001) and typically developing (R(2) = 0.77, p<0.001) groups. The slope of the relationship between muscle volume and body mass was significantly shallower in the cerebral palsy group compared to the typically developing group (p=0.007). CONCLUSIONS: This cross-sectional study suggests that the increase in size of lower limb muscles relative to body mass is reduced in adolescents and young adults with cerebral palsy. Longitudinal studies are required to further investigate altered muscle growth trajectories in this group and their impact on long-term mobility. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12883-017-1005-0) contains supplementary material, which is available to authorized users. BioMed Central 2017-12-29 /pmc/articles/PMC5747099/ /pubmed/29284423 http://dx.doi.org/10.1186/s12883-017-1005-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Noble, Jonathan J.
Chruscikowski, Emily
Fry, Nicola R. D.
Lewis, Andrew P.
Gough, Martin
Shortland, Adam P.
The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
title The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
title_full The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
title_fullStr The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
title_full_unstemmed The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
title_short The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
title_sort relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747099/
https://www.ncbi.nlm.nih.gov/pubmed/29284423
http://dx.doi.org/10.1186/s12883-017-1005-0
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